Acetyl-CoA protection assays indicated that Cd-dependent irreversible inhibition
of human NAT1 and NAT2 was due to the reaction of the metal with the reactive catalytic cysteine residue (Ragunathan et al.
Aspirin causes irreversible inhibition
of platelet function and other clotting disorders, so its use near term may result in enhanced maternal blood loss at delivery and an increase in the incidence of intracranial hemorrhage in premature or low-birthweight infants.
BRIEF BUTYLTIN EXPOSURE INDUCES IRREVERSIBLE INHIBITION
OF THE CYTOTOXIC FUNCTION OF HUMAN NATURAL KILLER CELLS, IN VITRO.
With irreversible inhibition
, the only way the enzyme activity can return to normal is by de novo synthesis of the enzyme by the cell," she said.
Our covalent drug platform has generated targeted small molecule inhibitors of PI3K, with specific and potent irreversible inhibition
and prolonged duration of action, and activity in vivo.
a biotechnology company developing novel targeted covalent drugs, has published research in Nature Chemical Biology demonstrating the first-ever selective irreversible inhibition
of a viral protease using a targeted covalent drug.