total iron-binding capacity

(redirected from Iron binding capacity)

total iron-binding capacity (TIBC),

an indirect method of determining the transferrin level in serum. Transferrin is saturated by the addition of iron to a serum specimen. Excess iron is removed, and the specimen is analyzed for iron content. The result is the total amount of iron that can be bound by transferrin. This result is helpful in differentiating anemias: high TIBC is associated with iron deficiency, low TIBC is associated with excess iron.

Farlex Partner Medical Dictionary © Farlex 2012

to·tal iron-bind·ing ca·pac·i·ty

(TIBC) (tō'tăl ī'ŏrn bīnd'ing kă-pas'i-tē)

An indirect method of determining the transferrin level in serum. Transferrin is saturated by the addition of iron to a serum specimen. Excess iron is removed, and the specimen is analyzed for iron content. The result is the total amount of iron that can be bound by transferrin. This result is helpful in differentiating anemias: high TIBC is associated with iron deficiency, low TIBC is associated with excess iron.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

References in periodicals archive ?

Measurement of serum iron and total iron binding capacity on a fasting, morning specimen should be performed as the initial test (1).

Hereditary hemochromatosis since discovery of the HFE gene

in their study showed that there was significant increase in serum iron, ferritin and transferrin saturation and decreased total iron binding capacity in the pre-eclamptic subjects, than the normal controls, when they compared 40 pre-eclamptic women with equal numbers of controls [22].

Serum iron and its possible link to the etiology of pregnancy induced hypertension

IDA was confirmed by serum iron profile consisting of serum ferritin, serum iron and total iron binding capacity

"Evaluation of intravenous iron versus oral iron in management of iron deficiency anemia in pregnancy with specific reference to body iron store"

TS was calculated by dividing serum iron by total iron binding capacity. Serum iron and total iron binding capacity were measured colorimetrically with an ALPKEM RFA analyzer (Alpkem), and 10 g/L thiourea was added to complex [Cu.sup+] to prevent copper interference (20).

Increased serum transferrin saturation is associated with lower serum transferrin receptor concentration

A recent study describing oversaturation of transferrin, as calculated by the measurement of high serum iron concentrations shortly after intravenous iron gluconate treatment, suggested that with this product, transferrin saturation is commonly >100% (serum iron/total iron binding capacity for transferrin binding sites X 100 = saturation) (3).

Comparison of methods used to measure serum iron in the presence of iron gluconate or iron

Measured versus calculated latent iron binding capacity in plasma of newborns.

The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferring concentrations in human serum

This finding emphasizes the clinical usefulness of the quantitation of the circulating receptor, as ferritin is a known acute-phase reactant [26,27], and concentrations of serum iron and transferrin or total iron binding capacity are known to decrease in the presence of an acute-phase reaction [28].

Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients

Biochemical serum markers, serum iron and serum total iron binding capacity were measured by Ferrozine-no deproteinization method by random access ADVIAA(r) 1800 Chemistry auto-analyzer.

FREQUENCY OF HFE GENE MUTATION IN IRON OVERLOAD PATIENTS

So, we need other sensitive & more specific indicators in detecting IDA which include reduction in serum iron, serum ferritin, transferrin saturation [TS] and increase in Total Iron Binding Capacity [TIBC] & soluble transferrin receptor levels.

PRE AND POST IRON THERAPY ABSOLUTE RETICULOCYTE COUNT--A RELIABLE TEST WITH EARLY RESPONSE TO TREATMENT IN IRON DEFICIENCY ANAEMIA

The diagnosis of ACD was accomplished by complete iron studies, including serum ferritin, serum iron, and total iron binding capacity (TIBC).

Serum hepcidin level and rheumatoid arthritis disease activity

In study group, hemoglobin (Hb), mean corpuscular volume (MCV), hematocrit (Hct), ferritin, unsaturated iron binding capacity (UIBC), serum iron level (SI) were analyzed in addition to routine blood exams for anesthesia.