total iron-binding capacity

(redirected from Iron binding capacity)

total iron-binding capacity (TIBC),

an indirect method of determining the transferrin level in serum. Transferrin is saturated by the addition of iron to a serum specimen. Excess iron is removed, and the specimen is analyzed for iron content. The result is the total amount of iron that can be bound by transferrin. This result is helpful in differentiating anemias: high TIBC is associated with iron deficiency, low TIBC is associated with excess iron.

to·tal iron-bind·ing ca·pac·i·ty

(TIBC) (tō'tăl ī'ŏrn bīnd'ing kă-pas'i-tē)
An indirect method of determining the transferrin level in serum. Transferrin is saturated by the addition of iron to a serum specimen. Excess iron is removed, and the specimen is analyzed for iron content. The result is the total amount of iron that can be bound by transferrin. This result is helpful in differentiating anemias: high TIBC is associated with iron deficiency, low TIBC is associated with excess iron.
References in periodicals archive ?
Measurement of serum iron and total iron binding capacity on a fasting, morning specimen should be performed as the initial test (1).
in their study showed that there was significant increase in serum iron, ferritin and transferrin saturation and decreased total iron binding capacity in the pre-eclamptic subjects, than the normal controls, when they compared 40 pre-eclamptic women with equal numbers of controls [22].
IDA was confirmed by serum iron profile consisting of serum ferritin, serum iron and total iron binding capacity
TS was calculated by dividing serum iron by total iron binding capacity. Serum iron and total iron binding capacity were measured colorimetrically with an ALPKEM RFA analyzer (Alpkem), and 10 g/L thiourea was added to complex [Cu.sup+] to prevent copper interference (20).
A recent study describing oversaturation of transferrin, as calculated by the measurement of high serum iron concentrations shortly after intravenous iron gluconate treatment, suggested that with this product, transferrin saturation is commonly >100% (serum iron/total iron binding capacity for transferrin binding sites X 100 = saturation) (3).
This finding emphasizes the clinical usefulness of the quantitation of the circulating receptor, as ferritin is a known acute-phase reactant [26,27], and concentrations of serum iron and transferrin or total iron binding capacity are known to decrease in the presence of an acute-phase reaction [28].
Biochemical serum markers, serum iron and serum total iron binding capacity were measured by Ferrozine-no deproteinization method by random access ADVIAA(r) 1800 Chemistry auto-analyzer.
So, we need other sensitive & more specific indicators in detecting IDA which include reduction in serum iron, serum ferritin, transferrin saturation [TS] and increase in Total Iron Binding Capacity [TIBC] & soluble transferrin receptor levels.
The diagnosis of ACD was accomplished by complete iron studies, including serum ferritin, serum iron, and total iron binding capacity (TIBC).
In study group, hemoglobin (Hb), mean corpuscular volume (MCV), hematocrit (Hct), ferritin, unsaturated iron binding capacity (UIBC), serum iron level (SI) were analyzed in addition to routine blood exams for anesthesia.
50 ml total iron binding capacity reagent 50 studies with a standard and a calibrator 100 ml, 120 byn4