The company added that SPRAVATO uses the first new mechanism of action and works on the N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor
in the brain.
As illustrated in figure 1, the DRGs are more implicated in signaling pathways; but the DRGs from frontal cortex were more enriched in ionotropic glutamate receptor
pathway and metabo-tropic glutamate receptor group II and III pathways.
NMDA receptors are the member of ionotropic glutamate receptor
family and are involved in many brain functions.
Different antagonist drugs for ionotropic glutamate receptor
were searched using the Solis and Wets local search method with a Lamarckian genetic algorithm (Solis and Wets, 1981).
However, when glutamatergic synapses within the RVLM were blocked by bilateral microinjections of kynurenic acid (0.02 mol/L, 100 nL), a broad-spectrum ionotropic glutamate receptor
antagonist, in hypertensive animals, no significant changes in MAP (from 174 [+ or -] 7 to 185 [+ or -] 10, n = 6) or in HR (from 413 [+ or -] 34 to 426 [+ or -] 24 bpm) were achieved.
(34) On the other hand, parallel fiber inputs activate not only the ionotropic glutamate receptor
but also metabotropic glutamate receptor mGluR1 at the postsynaptic membrane of a Purkinje cell.
Chronic prenatal ethanol exposure alters ionotropic glutamate receptor
subunit protein levels in the adult guinea pig cerebral cortex.
Characterization of ionotropic glutamate receptor
in rat hypothalamus, pituitary and immortalized gonadotropin-releasing hormone (GnRH) neurons (GT1-1 cells).
Cloning and characterization of an ionotropic glutamate receptor
subunit expressed in the squid nervous system.
HT22 cell, the immortalized mouse hippocampal cell line, which lack ionotropic glutamate receptor
is excellent model to evaluate oxidative glutamate toxicity.
Ionotropic glutamate receptor
antagonists modulate cue-induced reinstatement of ethanol-seeking behavior.