These synthetic ion transporters
, described this week in the journal Nature Chemistry, could point the way to new anticancer drugs while also benefitting patients with cystic fibrosis.
Table 1: Fractions of ion transporters
in the t-tubular membrane of rat ventricular cardiomyocytes as estimated from experimental measurements of ionic currents and membrane capacitances in intact and detubulated cells.
Indeed, perinatal DDT exposure induced the mRNA expression of several [Na.sup.+]/[H.sup.+] exchangers, two [Na.sup.+]/[K.sup.+]/[Cl.sup.-] cotransporters, a subunit of the [Na.sup.+]/[K.sup.+] ATPase, and a [Na.sup.+]/[Ca.sup.2+] exchanger in hypertensive kidneys (Figure 3B), consistent with elevated expression of renal ion transporters
in hypertension caused by an over-activated RAS (Rozansky 2006).
The introduction of ion transporters
has been successfully used to increase plant salt tolerance (Zhang & Blumwald, 2001), as highlighted in the review on Na homeostasis by Hasegawa (2013).
The team's analysis suggests that the prion gene is descended from the more ancient ZIP family of metal ion transporters
A decrease (compared with control at pH 7.8) of short-circuit current and transepithelial potential difference values was observed in the "in vitro" stripped intestine of freshwater-adapted Anguilla anguilla (Linnaeus, 1758) submitted to pH 7.0, indicating an inhibition of ion transporters
in this organ (Baldisserotto and Mimura, 1995).
In addition to drug discovery, the unit is also well suited for studies of ion transporters
, which comprise another type of membrane protein involved in transporting ions and other molecules across the lipid membranes of cells.
The noxious ions can be discharged from the cells or be compartmentalized into the organelles by the ion transporters
which are supported by the [H.sup.+]-ATPase.
Based on previous findings, we hypothesized that there should be a difference in the expression of epithelial ion transporters
and anion producers in the ED of postnatal wild type (WT) and estrogen receptor a knockout ([alpha]ERKO) mice.
We are currently using degenerate primers designed against two conserved regions, the phosphorylation site and the ATP-binding site, to amplify members of the P-type superfamily of ion transporters
. Thus far, all of our clones fall into the heavy-metal P-type class but may represent different metal transporters.