Cell and platforms performance as well as ion channel
current expression is thoroughly investigated and summarized in a data sheet.
Early work in the field, done to understand the ion channels
whose coordinated opening and closing creates a nerve impulse, was done in exceptionally large cells: the giant nerve cells of the European squid, which had projections big enough to be seen with the unaided eye.
In nerve cells, ion channels
work with extreme precision: Sodium channels open for a fraction of a second to allow just enough sodium in to trigger a nerve impulse.
Bett has shown in preliminary data that ion channel
expression changes 150-fold during gestation.
Because sour taste is the perception of acidic substances, which have a high concentration of protons, Liman predicted that sour taste cells have an ion channel
that responds to or transports protons.
First, we checked the major group, the most frequently investigated ion channels
, such as the Na, Ca, transient outward current ([I.sub.to]), delayed rectifier K current ([I.sub.Kr], [I.sub.Ks]), inward rectifier current ([I.sub.K1]), Na/Ca exchanger ([I.sub.NCX]), and funny current (If) channels.
After determining the impacts of potassium ion channels
on temporal coherence of network in the presence of autapse, we examine the effects of sodium ion channels
known as another important ion channels
at determining the firing dynamics of neuron.
Taugher et al., "Acid-sensing ion channels
contribute to synaptic transmission and inhibit cocaine-evoked plasticity," Nature Neuroscience, vol.
According to its different targets acting on the organism, the conotoxins can be divided into three categories : (1) acting on voltage-gated ion channels
, (2) acting on the ligand-gated ion channel
, and (3) acting on other receptors.
Peter Finan, chairman Enterprise Therapeutics, said, "John's experience in ion channels
, drug development, and biotech fundraising, position him uniquely to lead Enterprise Therapeutics moving forward.
Leading biomedical researchers based in Qatar, the Mena region, Europe and the Far East met for a conference on 'Ion Channels
and Transporters in Health and Disease'.