intravascular large B-cell lymphoma


Also found in: Dictionary, Acronyms.
Related to intravascular large B-cell lymphoma: Primary effusion lymphoma

intravascular large B-cell lymphoma

A high-grade non-Hodgkin lymphoma arising in and generally confined to vascular lumina, which usually begins in the skin and CNS and rapidly spreads elsewhere.

Clinical findings
Often begins with fever of unknown origin and nonspecific cutaneous (e.g., plaques) and neurologic complaints.
 
DiffDx
Skin lesions (erythematous/purple plaques on the trunk and lower legs) may be confused with mycosis fungoides, sarcoidosis, vascular neoplasms (e.g., Kaposi sarcoma) or involvement by lymphoma or leukaemia.

Prognosis
Extremely poor; short survival is the norm despite aggressive chemotherapy. The diagnosis is often established postmortem.
References in periodicals archive ?
Intravascular large B-cell lymphoma is a rare type of extranodal large B-cell lymphoma.
Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5.
Prostatic acid phosphatase: a possible diagnostic marker of intravascular large B-cell lymphoma.
Prostatic acid phosphatase is a possible tumor marker for intravascular large B-cell lymphoma.
Analysis of the immunoglobulin heavy chain gene variable region of intravascular large B-cell lymphoma.
Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma.

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