A phase I/II study of direct intra-arterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma
- initial results.
Figure 35: Chemoreduction and Local Ophthalmic Therapy for Intraocular Retinoblastoma
- CHP-582 43
There are few studies that have evaluated HRFs in eyes enucleated for advanced intraocular retinoblastoma from developing countries, and most of them have reported higher incidences compared with studies reported in the Western literature.
The credibility of our study is that we have included only primarily enucleated eyes and thus incidence of HRFs reported in our series could truly represent the risk for metastasis in patients undergoing enucleation for advanced intraocular retinoblastoma.
A clinicopathological correlation of 67 eyes primarily enucleated for advanced intraocular retinoblastoma [published online ahead of print August 7, 2010].
As retinoblastomas form within the retina, we hypothesized that sd-rxRNAs might also regulate gene expression in intraocular retinoblastoma
Combined chemotherapy and local treatment in the management of intraocular retinoblastoma.
Intraocular retinoblastoma group V: an analysis of prognostic factors.
Pilot studies of chemotherapy for intraocular retinoblastoma
have been reported from several groups using different combinations, dosages, schedules and duration of carboplatin, etoposide or teniposide, with or without vincristine, and with or without cyclosporine to counteract multidrug resistance.
Only patients with unilateral advanced intraocular retinoblastoma
that have received no previous treatment will be eligible for clinical trial enrollment.
The protocol of chemotherapy is the same as that used for chemoreduction of intraocular retinoblastoma (12); the protocol is changed to 12 cycles of high-dose chemotherapy for patients with involvement of the optic nerve to the transection line and scleral and extrascleral extension.
Chemoreduction in the initial management of intraocular retinoblastoma.