The glomerular capillary walls are thickened secondary to the intramembranous
deposits in the lamina densa of the GBM.
Endochondral ossification predominates over intramembranous
ossification in this region.
bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling.
In advanced cases of class V, double contours of the capillary walls may be seen due to intramembranous
deposits, fusion of spikes, and new basement membrane formation.
Along the basement membrane, immune complex deposits can be seen in the subepithelial, intramembranous
, and subendothelial distribution (Fig.
Reorientation, shape change, ConA receptor and intramembranous
particle distribution and cytoskeleton reorganization.
A model for intramembranous
ossification during fracture healing.
Although the bone histology is normal in the first generation of homozygotes, the second generation show an accumulation of osteoid tissue at sites of intramembranous
ossification, such as in the calvaria, clavicle, mandible, and periosteal surface of long bones.
The plasma membrane at the tip of Lepidium sativum root hairs consists of numerous "blisters," sites of vesicle fusion, which are largely free of intramembranous
particles in freeze-fractured samples; randomly arranged intramembranous
particles are present outside these regions (Volkmann, 1984).
Meckel's cartilage grows back to meet a primary jaw joint and becomes enveloped by intramembranous
Light Microscopy of GBM) nm 1 No GS; no other LM Focal mild splitting 204 changes 2 20% global GS; focal None 196 mild IF 3 No GS; focal mild IF None 214 4 30% global GS; focal None 192 mild to moderate IF 5 5% global GS; no Focal mild splitting 161 other LM changes 6 9% global GS; focal None 186 minimal to mild IF 7 5% global GS; no IF None 231 8 20% global GS and Focal mild splitting 239 focal and segmental and rare GS; mild IF intramembranous
granular inclusions 9 12% global GS and Focal mild splitting 179 focal and segmental and rare GS; focal minimal IF intramembranous
granular inclusions (*) GBM indicates glomerular basement membrane; GS, glomerulosclerosis; LM, light microscopic; and IF, interstitial fibrosis.
Electron microscopy disclosed numerous, large, subepithelial and intramembranous
electron-dense deposits along the glomerular capillary walls.