signal transduction

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signal transduction

n.
The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.
See also: transduction
Medical Dictionary, © 2009 Farlex and Partners

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating cell cycle, proliferation and apoptosis.
Subsequently, the intracellular signaling pathways activated in hAMSC due to exposure of ELF-PEMF were examined.
Wnt proteins stimulate intracellular signaling pathways, regulate gene expression in the nucleus, and determine cell fate.
Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells.
Experiments in isolated human T cells demonstrated that these GLUT inhibitors blocked the secretion of pro-inflammatory cytokines, such as IL-17 and TNF-alpha, and modulated key intracellular signaling pathways in pathogenic T cells, including STAT1, STAT3 and S6K.
Taken together, these studies indicate that SCI produces long-lasting or persistent hyperactivity of spinal dorsal horn sensory neurons via altered intracellular signaling pathways. In particular, activation of PL[A.sub.2]-ROS pathways perpetuate receptor/ion channel activation and membrane property changes via transcriptional/translational events that modulate the expression of specific genes and proteins, making glutamate receptor-bearing neuronal membranes hyperexcitable after SCI.
Tetraspanins in TERMs can form massive protein-protein complexes that transduce extracellular signals to intracellular signaling pathways [1].
These receptors couple the binding of the extracellular growth factor ligands to intracellular signaling pathways that control various biologic responses such as proliferation, differentiation, cell motility, and survival [40-45].
focus in their work on the effect of hypoxia on intracellular signaling pathways responsible for mouse embryonic stem (ES) cell maintenance.
It also plays an important role in cholesterol homeostasis and vesicular transport, but could also combine with a variety of signaling molecules which would activate or inhibit different intracellular signaling pathways, and regulate the expression of related genes (Fridolfsson et al., 2014; Liu et al., 2012).
Antioxidants can have remarkable effects on the intracellular signaling pathways involved in preventing skin damage.
(5) Copper is toxic in its unbound form, causes redox imbalance due to its highly redox active nature, which leads to activation of stress sensitive intracellular signaling pathways through Haber-Weiss reaction (6,7) The present study was undertaken to study the relationship between fasting plasma glucose (FPG) and copper with ceruloplasmin in type 2 DM patients

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