signal transduction

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signal transduction

n.
The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.
See also: transduction

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.
References in periodicals archive ?
The company said IRESSA is a once-daily oral medication that targets and blocks the activity of epidermal growth factor receptor-tyrosine kinase (EGFR-TK), an enzyme that regulates the intracellular signaling pathways implicated in cancer cell proliferation and survival.
The intracellular signaling pathways mediating the physiologic function of OXs and their receptors have been under intense investigation.
CREB is a transcription factor in nucleus, and also a major intersection point in the intracellular signaling pathways associated with depression.
The topics include the neuroendocrinology of hydromineral homeostasis, diverse roles of angiotensin receptor intracellular signaling pathways in the control of water and salt intake, catecholaminergical medullary pathways and cardiovascular response to expanded circulating volume and increased osmolarity, brain serotonergic receptors and the control of fluid intake and cardiovascular function in rats, and sodium appetite sensitization.
Taken together, our data suggest that the antiproliferative effect of NAC is partially mediated by intracellular ROS production, the inhibition of NF-kB activity, and the activation of PI3K- and/or MEK/Erk-related intracellular signaling pathways, which lead to up-regulation of Cyr61 expression.
PerFix-Expose, which helps scientists identify and explore complex intracellular signaling pathways disrupted by cancer and other diseases, allows fluorochrome-coupled antibodies and other probes to enter into cells, their nuclei and other cell compartments, where they bind to proteins relevant to signaling pathways that have been disrupted by disease.
Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.
Studies in laboratory animals have reported altered behavior, synaptic plasticity, developmental neuroanatomical processes, neurotransmitter release/update, ion-channel functioning, calcium homeostasis, and intracellular signaling pathways after exposure to PBDEs.
Its research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms.
Genentech is a leading innovator of important new cancer therapies, and we believe that this collaboration validates the significant potential of XL518 to be the first in a new class of drugs targeting critical intracellular signaling pathways," said George A.
Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms.

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