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Levonelle (UK), Mirena, Plan B One-Step

Pharmacologic class: Contraceptive, intrauterine device (Mirena); oral contraceptive, progestin-only pill (Plan B)

Therapeutic class: Contraceptive

Pregnancy risk category X (Mirena), NR (Plan B)


Plan B -


Unclear. Mirena may enhance local contraceptive efficacy by thickening the cervical mucus (which prevents passage of sperm into uterus), inhibiting sperm capacitation or survival, and altering the endometrium. Plan B is thought to prevent ovulation or fertilization.


Intrauterine system (Mirena): 52 mg levonorgestrel

Tablets (Plan B): 1.5 mg

Indications and dosages

Intrauterine contraception for up to 5 years; heavy menstrual bleeding for women who choose to use intrauterine contraception

Adults: One intrauterine system (Mirena) inserted into uterus for up to 5 years

Emergency contraception to prevent pregnancy

Adults: 1.5 mg (Plan B) P.O. as soon as possible within 72 hours after unprotected intercourse



• Hypersensitivity to drug or its components

• Known or suspected pregnancy

• Congenital or acquired uterine anomaly

• Acute pelvic inflammatory disease (PID) or history of PID (unless patient had subsequent intrauterine pregnancy)

• Postpartum endometritis or infected abortion within past 3 months

• Known or suspected uterine or cervical neoplasia or unresolved abnormal Papanicolaou (Pap) test

• Untreated acute cervicitis or vaginitis

• Acute hepatic disease or hepatic tumor (benign or malignant)

• Genital bleeding of unknown cause

• Conditions associated with increased risk of infection

• Genital actinomycosis

• Previously inserted intrauterine device that has not been removed

• Known or suspected breast cancer

• History of ectopic pregnancy or conditions that predispose to it

Plan B -

• Hypersensitivity to drug or its components

• Known or suspected pregnancy

• Undiagnosed abnormal genital bleeding


Use Mirena cautiously in:

• diabetes mellitus

• breastfeeding patients.

Use Plan B cautiously in:

• coagulopathy

• diabetes mellitus

• patients receiving anticoagulants concurrently.


• Know that Mirena should be inserted under aseptic conditions by health care professional familiar with procedure.

• Verify that patient isn't pregnant before Mirena insertion.

• Know that Plan B should be given as soon as possible within 72 hours of unprotected sexual intercourse. Drug isn't suitable as long-term contraceptive.

Adverse reactions

CNS: headache (Mirena, Plan B), fatigue, dizziness (Plan B), severe headache, migraine, nervousness, depression (Mirena)

CV: hypertension (Mirena)

EENT: sinusitis (Mirena)

GI: nausea, vomiting, abdominal pain (Mirena, Plan B), diarrhea (Plan B), intestinal perforation or obstruction (Mirena)

GU: breast tenderness (Mirena, Plan B); lighter or heavier menstrual bleeding (Plan B); breast pain; increased progesterone levels; ovarian cysts; dysmenorrhea; amenorrhea; spotting; erratic or prolonged menstrual bleeding; pelvic infection; vaginitis; cervicitis; dyspareunia; leukorrhea; decreased libido; abnormal Pap smear; expulsion, embedment in myometrium, adhesions, cervical or ureteral perforation (Mirena)

Hematologic: anemia (Mirena)

Hepatic: jaundice (Mirena)

Musculoskeletal: back pain (Mirena)

Respiratory: upper respiratory tract infection (Mirena)

Skin: skin disorder, acne, eczema, hair loss (Mirena)

Other: water retention, weight gain, sepsis (Mirena)


Drug-drug. Hepatic enzyme-inducing drugs (such as barbiturates, carbamazepine, phenytoin, rifampin): decreased Plan B efficacy

Drug-diagnostic tests. Glucose: altered level (Mirena)

Patient monitoring

• Monitor blood pressure.

• Watch for adverse reactions, especially changes in menstrual bleeding.

• Monitor blood glucose level in diabetic patients.

• Check liver function tests frequently.

Patient teaching

• Tell patient taking either product that drug does not prevent HIV or other sexually transmitted diseases.

• Teach patient using Mirena how to check (after menstrual period) to make sure thread still protrudes from cervix. Caution her not to pull on thread, because this could cause displacement.

Instruct patient using Mirena to immediately report fever, chills, unusual vaginal discharge, or abdominal or pelvic pain or tenderness.

• Explain that for maximum efficacy, patient should take Plan B as soon as possible after unprotected sex.

• Inform patient that Plan B isn't intended for routine contraception and doesn't terminate existing pregnancy.

• Tell patient to report adverse reactions.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A so-called hormonal-type intrauterine contraceptive system, consisting of a plastic T-shaped device that is inserted into the uterus and slowly releases levonorgestrel, a synthetic progesterone analogue, ensuring that the woman remains inconceivable for up to five years.

Adverse effects
Acne, back pain, breast pain/tenderness, menstrual spotting, reduced libido, dizziness, bleeding, headache, nausea, vomiting, weight gain.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


A brand name for a T-shaped intrauterine contraceptive system with a hormone reservoir that slowly releases LEVONORGESTREL, providing five-year, contraception.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
However, levonorgestrel intrauterine system was found more effective in reducing menstrual blood loss in 36(94.73%) patients, compared to norethisterone-treated patients 28(73.68%) after 6 months of the treatment (p=0.041).
In the same month, Allergan and Medicines360 announced that they will donate 10,000 units of their hormonal intrauterine device Liletta (levonorgestrel-releasing intrauterine system) to the US Centers for Disease Control (CDC) Foundation in response to the Zika virus growing prevalence in Puerto Rico.
Keywords: Dysfunctional uterine bleeding, Mirena, Levonorgestrel-releasing intrauterine system.
The third missing essential is an intrauterine device (IUD) or intrauterine system (IUS) the dimensions of which will accommodate the nulliparous or smaller uterus to provide a more anatomical fit.
Council-developed contraceptive products include the Copper T intrauterine device (IUD), the levonorgestrel intrauterine system known as Mirena[R], and the implants Jadelle[R] and Norplant[R].
Actavis PLC and Medicines360, a nonprofit women's health pharmaceutical company, have announced the approval of Liletta (levonorgestrel-releasing intrauterine system) by the Food and Drug Administration for use by women to prevent pregnancy for up to three years.
The fourth generation of IUDs will be defined by their ability to provide an added health benefit to an intrauterine system, not just an improvement in tolerability of the intrauterine device and some tangential benefits in helping reduce uterine problems like the third generation IUDs do.
The participants were randomized to either hysterectomy or treatment with a levonorgestrel-releasing intrauterine system such as Mirena(r).
** introduction of the levonorgestrel intrauterine system (LNG-IUS) as a referral method, o introduction of combined oestrogen and progestogen injectables;
Skyla is the newest intrauterine system on the market.
Three cases (13%) were man- aged with MIRENA (levonorgestrel releasing intrauterine system).