collagenase

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collagenase

 [kŏ-laj´ĕ-nās]
an enzyme that catalyzes the degradation of collagen.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

col·la·gen·ase

(kol-ăj'ĕ-nās),
A proteolytic enzyme that acts on one or more of the collagens.
Farlex Partner Medical Dictionary © Farlex 2012

collagenase

(kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

matrix metalloproteinase 1

A 43-kD tissue enzyme (EC 3.4.24.7), encoded by MMP1 on chromosome 11q21-q22, which cleaves collagens, cytokines and extracellular matrix.

Cytokine inducers 
BTC, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF, HRG-β1, IFN-β, IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, sIL-6 Rα, IL-8, IL-10, MIF, oncostatin M, PD-ECGF, PDGF, PDGF-AA, PDGF-BB, PF4, TGF-α, TGF-β1, TNF-α, TNF-β, VEGF.
 
Substrates
3 α-chains of native Collagens I, II, III, VII, VIII and IX; gelatin, aggrecan, hyaluronidase-treated versican, proteoglycan link protein, large tenascin-C, α1-antitrypsin/α1-proteinase inhibitor (α1-AT), α1-antichymotrypsin, pregnancy zone protein, ovostatin, entactin/nidogen, MBP, GST-TNF/TNF peptide, l-selectin, serum amyloid A, IGF-BP3, IGF-BP5, IL-1β, MMP-2, MMP-9.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on one or more of the collagens.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on collagens.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
REGULATION OF INTERSTITIAL COLLAGENASE PROMOTER ACTIVITY BY TAMOXIFEN IN NORMAL UTERINE ENDOMETRIAL CELLS
The objective of this study was to determine the effects of Tamoxifen on interstitial collagenase expression in normal uterine endometrial cells.
The purpose of this study was to examine the effects of tamoxifen on expression of interstitial collagenase and growth factors (TGF-[beta] TGF-[alpha] EGF, MMP-1) in breast cancer cells.

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