collagenase

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collagenase

 [kŏ-laj´ĕ-nās]
an enzyme that catalyzes the degradation of collagen.

col·la·gen·ase

(kol-ăj'ĕ-nās),
A proteolytic enzyme that acts on one or more of the collagens.

collagenase

(kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.

matrix metalloproteinase 1

A 43-kD tissue enzyme (EC 3.4.24.7), encoded by MMP1 on chromosome 11q21-q22, which cleaves collagens, cytokines and extracellular matrix.

Cytokine inducers 
BTC, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF, HRG-β1, IFN-β, IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, sIL-6 Rα, IL-8, IL-10, MIF, oncostatin M, PD-ECGF, PDGF, PDGF-AA, PDGF-BB, PF4, TGF-α, TGF-β1, TNF-α, TNF-β, VEGF.
 
Substrates
3 α-chains of native Collagens I, II, III, VII, VIII and IX; gelatin, aggrecan, hyaluronidase-treated versican, proteoglycan link protein, large tenascin-C, α1-antitrypsin/α1-proteinase inhibitor (α1-AT), α1-antichymotrypsin, pregnancy zone protein, ovostatin, entactin/nidogen, MBP, GST-TNF/TNF peptide, l-selectin, serum amyloid A, IGF-BP3, IGF-BP5, IL-1β, MMP-2, MMP-9.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on one or more of the collagens.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on collagens.
References in periodicals archive ?
REGULATION OF INTERSTITIAL COLLAGENASE PROMOTER ACTIVITY BY TAMOXIFEN IN NORMAL UTERINE ENDOMETRIAL CELLS
The objective of this study was to determine the effects of Tamoxifen on interstitial collagenase expression in normal uterine endometrial cells.
The purpose of this study was to examine the effects of tamoxifen on expression of interstitial collagenase and growth factors (TGF-[beta] TGF-[alpha] EGF, MMP-1) in breast cancer cells.

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