a gene whose coding sequence is interrupted, at intervals, by non-coding sequences (INTRONS), the number and size of which vary Such sequences are found in the PRIMARY TRANSCRIPT of the gene, but not in the mature transcript after SPLICING. Interrupted genes are characteristic of many EUKARYOTES. They may also be found less frequently in certain PROKARYOTES. Also called discontinuous gene or split gene.
(27) The formation of NMD as a direct consequence of interrupted genes makes sense and an examination of the NMD machinery shows components constructed from archaeal translation systems and eubacterial post-segregation killing systems.