intermediate filament

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intermediate filament

n.
Any of a group of protein filaments that are a component of the cytoskeleton in animal cells, are composed of a variety of proteins such as lamins and keratins, and provide structural support for the cytoplasm and nucleus. Intermediate filaments are intermediate in diameter between microfilaments and microtubules, the other components of the cytoskeleton.

intermediate filament

Abbreviation: IF
Slender proteins found in all eukaryotic cells, measuring about 8 to 12 nm in diameter. Intermediate filaments are composed of proteins including desmin, keratins, lamins, and vimentin and together with microtubules and microfilaments form the cytoskeleton. Some malignant cells can be identified by the specific proteins in their intermediate filaments.
See also: filament
References in periodicals archive ?
Modulation of Intermediate Filament Proteins by Retinoids in Prostate Cancer.
Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins. J.
BORISY: A second question is, if intermediate filament proteins are the major binding partner for plectins, how do you explain the phenotype of the vimentin knockout mouse reported in the literature?
Expression of intermediate filament proteins in subtypes of renal cell carcinoma and in renal oncocytomas: distinction of two classes of renal cell tumors.
The origin of mixed tumors from most sites has been ascribed to myoepithelial cells.[2,3] These mixed tumors may show variable amounts of epithelial and mesenchymal components, which not uncommonly show chondroid and osseous differentiation.[2,3] They not only coexpress vimentin and cytokeratin but, at least in areas, coexpress [Alpha]-smooth muscle actin and/or S100 protein.[2,3] In addition, they commonly coexpress other intermediate filament proteins such as glial filament acidic protein.[3]
gigantea were also probed with monoclonal antibodies to the microtubule-associated proteins, anti-MAP2 and anti-tau, and with a monoclonal antibody (anti-IFA; Pruss et al., 1981) known to bind to most of the defined major intermediate filament proteins. MAP2 isolated from rat brain consists of two major polypeptides (MAP2a and MAP2b) of similar molecular weights, approximately 275 kD, although proteolysis can result in a 35 kD domain and a major 240 kD domain (Vallee, 1980).
Expression of four different types of intermediate filament proteins within the same cell type.
Cytokeratins are well-described intermediate filament proteins of both normal epithelia and epithelial tumors.

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