interleukin-8


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in·ter·leu·kin-8

(in'tĕr-lū'kin),
A cytokine derived from endothelial cells, fibroblasts, keratinocytes, macrophages, and monocytes that causes chemotaxis of neutrophils and T-cell lymphocytes.
Synonym(s): anionic neutrophil-activating peptide, monocyte-derived neutrophil chemotactic factor, neutrophil chemotactant factor, neutrophil-activating factor

IL8

A gene on chromosome 4q13-q21 that encodes interleukin-8, a cytokine belonging to the CXC chemokine family. IL8 is a major mediator of inflammation, acting as a chemoattractant for neutrophils, basophils and T-cells, and is a potent angiogenic factor.

Molecular pathology
IL8 is a candidate gene for bronchiolitis.

in·ter·leu·kin-8

(in'tĕr-lū'kin)
A cytokine derived from endothelial cells, fibroblasts, keratinocytes, macrophages, and monocytes that causes chemotaxis of neutrophils and T-cell lymphocytes.
Synonym(s): anionic neutrophil-activating peptide, monocyte-derived neutrophil chemotactic factor, neutrophil-activating factor.

interleukin-8

A CYTOKINE produced by MONOCYTES that is the substance causing CHEMOTAXIS of T cells and NEUTROPHIL polymorph phagocytes.
References in periodicals archive ?
Prognostic significance of interleukin-8 and CD163-positive cell-infiltration in tumor tissues in patients with oral squamous cell carcinoma.
Effect of the use of snuff on the levels of interleukin-1 beta and interleukin-8 in the gingival crevicular fluid of periodontitis patients.
Interleukin-1 and interleukin-8 in nicotine-and lipopolysaccharide-exposed gingival keratinocyte cultures.
* The report reviews C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin-8 Receptor B or IL-8 Receptor Type 2 or CD182 or CXCR2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
(29.) Wang LM, Kitteringham N, Mineshita S et al: The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behcet's disease.
(30.) Gur-Toy G, Lenk N, Yalcin B, Aksaray S, Alli N: Serum interleukin-8 as a serologic marker of activity in Behcet's disease.
(31.) Durmazlar SPK, Ulkar GB, Eskioglu F, Tatlican S, Mert A, Akgul A: Significance of serum interleukin-8 levels in patients with Behcet's disease: high levels may indicate vascular involvement.
The report provides comprehensive information on the C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin-8 Receptor A or IL-8 Receptor Type 1 or CD181 or CXCR1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
* The report provides a snapshot of the global therapeutic landscape for C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin-8 Receptor A or IL-8 Receptor Type 1 or CD181 or CXCR1)
The researchers observed that the double insult to the cells of both rhinovirus and one of the two pollutants resulted in an enhanced release of cytokines, particularly interleukin-8 and the surface expression of intercellular adhesion molecule 1.
When white blood cells encounter lipid A, they make a cascade of proteins -- such as tumor necrosis factor (TNF), interleukin-1, interleukin-6, and interleukin-8 - that stimulate the immune system.