interleukin-7


Also found in: Dictionary, Thesaurus, Encyclopedia.

in·ter·leu·kin-7

(in'tĕr-lū'kin),
A cytokine derived from bone marrow cells that causes proliferation of B and T lymphocytes.

IL7

A gene on chromosome 8q12-q13 that encodes interleukin-7, a hematopoietic growth factor which stimulates the proliferation of lymphoid progenitors, including both B and T cells. It forms a heterodimer with hepatocyte growth factor to act as a pre-pro-B-cell growth-stimulating factor. It is also a cofactor for V(D)J rearrangement of the T-cell receptor beta during early T-cell development. IL7 is produced locally by intestinal mucosal cells, and may act as a regulatory factor for intestinal mucosal (GALT) lymphocytes.

in·ter·leu·kin-7

(in'tĕr-lū'kin)
A cytokine derived from bone marrow cells that causes proliferation of B and T lymphocytes.

interleukin-7

A CYTOKINE produced by the bone marrow stromal cells responsible for the proliferation of B cell precursors, helper and cytotoxic T cells and activated mature T cells.
References in periodicals archive ?
Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians.
The variant of the interleukin-7 receptor gene seems to slightly favor production of a free-floating, or soluble, version of the receptor.