IL26

(redirected from Interleukin-26)

IL26

A gene on chromosome 12q15 that encodes a protein belonging to the IL10 family of cytokines thought to have a pro-inflammatory role in mucosal immunity; it is inhibited by heparin. IL26:
• Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT;
• Induces expression of SOCS3, TNF-alpha and IL-8;
• Induces secretion of IL-8 and IL-10 and surface expression of ICAM1; and
• Decreases proliferation of intestinal epithelial cells.

Molecular pathology
IL26 may play a role in inflammatory bowel disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
'Enhanced local production of interleukin-26 in uncontrolled compared with controlled adult asthma'.