IL21

(redirected from Interleukin-21)

IL21

A gene on chromosome 4q26-q27 that encodes IL-21, a cytokine with immunoregulatory activity that may promote the transition between innate and adaptive immunity. IL21 induces the production of IgG1 and IgG3 in B cells, and may play a role in proliferation and maturation of natural killer cells in synergy with IL15. It is also a less preferred gene symbol for what is now designated as IL17C (see there), as well as IL22 (see there).
References in periodicals archive ?
demonstrated, in an experimental model with Mycobacterium tuberculosis stimulated CD4+ and NK T cells, that Interleukin-21 activated NK cells, and also enhances the immune response by augmenting IL-1[beta], IL-18, and MIP-1[beta] production, and reducing IL-10 production by monocytes in response to an intracellular pathogen.
Leonard, "Interleukin-21: a double-edged sword with therapeutic potential," Nature Reviews.
Leonard, "Calcium-dependent activation of interleukin-21 gene expression in T cells," The Journal of Biological Chemistry, vol.
Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on [CD4.sup.+] cutaneous T-cell lymphoma cells.
Increased production of interleukin-21, but not interleukin17A, in the small intestine characterizes pediatric celiac disease.
Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis.
Among the promising treatments currently in development is a medicine for type 1 diabetes that targets the protein interleukin-21 (IL-21), which plays a role in inter-cell communication as well as regulating the immune system.
showed that interleukin-21 receptor (IL-21R) is upregulated in endothelial cells from ischemic hind-limb muscle in mice and that loss of IL-21R resulted in impaired perfusion recovery (72).
Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4 + cutaneous T-cell lymphoma cells.
Monteleone, "Role of interleukin-21 in inflammation and allergy," Inflammation and Allergy--Drug Targets, vol.
The contributors review research findings on protein tyrosine phosphatases, interleukin-21, class switch recombination, thymus organogenesis, somatic hypermutation, and T follicular helper cells.
Shirzad et al., "Mucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity of gastritis," Central European Journal of Immunology, vol.