interleukin-18


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Related to interleukin-18: Il-18

in·ter·leu·kin-18

(in'tĕr-lū'kin),
A cytokine produced by macrophages; a potent inducer of interferon-γ by T cells and NK cells.

IL18

A gene on chromosome 11q22.2-q22.3 that encodes IL-18, a proinflammatory cytokine that increases natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

in·ter·leu·kin-18

(in'tĕr-lū'kin)
A cytokine made by macrophages; a potent inducer of interferon-γ by T cells and natural killer cells.

interleukin-18

Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.
See also: interleukin

interleukin-18

,

IL-18

A cytokine produced by macrophages that stimulates the production of gamma interferon (IFN?) and other chemical mediators that enhance cell-mediated immune responses. Interleukin-18 is similar in structure to IL-1.
References in periodicals archive ?
Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.
Interleukin-18 promoter polymorphisms and risk of ischemic stroke.
Interleukin-18 involvement in hypoxic-ischemic brain injury.
Box plots of (a) urinary neutrophil gelatinase-associated lipocalin (NGAL), (b) interleukin-18 (IL-18), and (c) kidney injury molecule-1 (KIM-1) by acute kidney injury (AKI) status.
Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma.
Dinarello, "Interleukin-18 and the pathogenesis of inflammatory diseases," Seminars in Nephrology, vol.
Hagberg, "Interleukin-18 involvement in hypoxic-ischemic brain injury," The Journal of Neuroscience, vol.
Okamura et al., "Interleukin-18 enhances the production of interleukin-8 by eosinophils," European Journal of Immunology, vol.
Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.
[12] reported that levels of interleukin-18, which is largely regarded as a product of macrophages [13], are significantly higher during the active stage of pediatric ISSNS compared to remission and controls.
They hypothesized that interleukin-18 may have an important role in the pathogenesis of HLH with SLE.
Nishizaki, "Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices," Brain Research, vol.