interleukin-10


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in·ter·leu·kin-10

(in'tĕr-lū'kin),
A cytokine derived from helper T-cell lymphocytes (Th2) that inhibits γ-interferon (IFNγ) and IL-2 secretion by T-cell lymphocytes (Th1) and inhibits mononuclear cell inflammation.

IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

in·ter·leu·kin-10

(in'tĕr-lū'kin)
A cytokine derived from helper T-cell lymphocytes, B-cell lymphocytes, and monocytes that inhibits interferon gamma; (IFNγ) secretion by T-cell lymphocytes and it inhibits mononuclear cell inflammation.

interleukin-10

A CYTOKINE produced by helper T cells, B cells, MACROPHAGES, and the placenta that inhibits gamma-interferon secretion and mononuclear cell inflammation.
References in periodicals archive ?
Wraith, "Regulation of adaptive immunity; the role of interleukin-10," Frontiers in Immunology, vol.
Preeclampsia is associated with a reduced interleukin-10 production from peripheral blood mononuclear cells.
Interleukin-10 (IL-10) has a complex and predominantly opposing roles in inflammation and plays a major role in suppressing immune and inflammatory responses (6).
Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.
Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis.
Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes.
Interleukin-10 is widely known as an immunosuppressive cytokine by virtue of its ability to inhibit macrophage-dependent antigen presentation, T-cell proliferation, and Th1 cytokine secretion (6).
Interleukin-10 inhibition of the progression established collagen induced arthritis.
The immunological status of PKDL patients continues to be characterized but the picture is complex with mixed T cell responses and elevated levels of interleukin-10 (IL-10) and tumour necrosis factor alpha (TNF-[alpha]) (6-9).
The results from a recent open-label study of 10 patients with mild to moderate Crohn's disease showed that treatment for 3 weeks with 15 g/day of a 30% inulin/70% oligofructose combination supplement was associated with improved disease activity and increased expression of the anti-inflammatory interleukin-10, which is expressed in dendritic cells (Gut 2006;55:348-55).
"But studies have already shown that vitamin D can lower inflammation by increasing levels of anti-inflammatory messengers like the cytokine named IL-10 (interleukin-10).
Specific proinflammatory cytokines (e.g., interleukin-10) and gender differences are also treated.