CASP1

(redirected from Interleukin-1 Beta-Converting Enzyme)
Also found in: Acronyms.

CASP1

A gene on chromosome 11q23 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development.

Molecular pathology
CASP1 mutations may play a role in Huntington’s disease.
References in periodicals archive ?
Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1 beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cells.