IL1B

(redirected from Interleukin-1 Beta)
Also found in: Acronyms.

IL1B

A gene on chromosome 2q14 that encodes interleukin-1B, a cytokine produced by activated macrophages as a proprotein, which is proteolytically activated by caspase 1 (CASP1/ICE). IL-1B is a key mediator of inflammation and is involved in an array of cellular activities, including cell proliferation, differentiation and apoptosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The proinflammatory effect of 5-FU upon the cheek pouch was detected as an increase in myeloperoxidase activity (A) and the production of tumor necrosis factor-alpha (TNF-[alpha]) (B) and interleukin-1 beta (IL-1[beta]) (C).
Fan, "Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes," International Orthopaedics, vol.
Gerashchenko, "Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression," Neuroscience Letters, vol.
More than a half of the positive results or increased levels of 4 of 7 minimum required cardiac markers (cardiac troponin I, creatine kinase MB, myoglobin, C-reactive protein, soluble intracellular adhesion molecular protein-1, interleukin-1 beta, fatty acid binding protein) indicate the risk of development of cardiovascular accidents and the need for emergent medical care.
Gevokizumab binds strongly to interleukin-1 beta (IL-1 beta), a pro-inflammatory cytokine, and modulates the cellular signalling events that produce inflammation.
Du et al., "Interleukin-1 beta increases activity of human endothelial progenitor cells: involvement of [PI.sub.3] K-Akt signaling pathway," Inflammation, vol.
DuBois, "Prostaglandin E (PGE) and interleukin-1 beta (IL-1 beta) levels in gingival crevicular fluid during human orthodontic tooth movement," The American Journal of Orthodontics and Dentofacial Orthopedics, vol.
The aim of our study was to investigate the possible in vitro effects of the VW in human OA chondrocytes cultivated in the presence or in the absence of Interleukin-1 beta (IL-1[beta]).
Mark Erwin DC, PhD, a researcher quite capable of talking well above my head in terms like, "interleukin-1 beta and Fas-Ligand" and how they factor in degenerative disc disease.
-- Gevokizumab (XOMA 052), a humanized antibody that binds to the inflammatory cytokine interleukin-1 beta, or IL-1 beta.