IL6

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IL6

A gene on chromosome 7p21 that encodes interleukin-6, a cytokine which plays a role in the acute-phase response of inflammation and in B-cell maturation. It is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through Il-6 receptor alpha.

Molecular pathology
IL6 dysfunction is linked to increased susceptibility to diabetes and juvenile rheumatoid arthritis.
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References in periodicals archive ?
Eight of the 17 athletes with concussion and high interleukin 6 levels at six hours after their head injury still had concussion symptoms eight days later, the investigators found.
"These results demonstrate a meaningful increase in the levels of interleukin 6 for athletes who sustained a concussion compared to athletes who did not," Meier said in a journal news release.
They also found strong correlations between C-reactive protein levels and interleukin 6 levels.
They found that fasting blood glucose and interleukin 6 levels in particular were good predictors of tumour aggression.
Determination of interleukin 6 (IL-6) in serum samples from the three experimental treatments indicated a significant affect of diet on studied parameter (P = 0.004).
The biological effects of interleukin 6. Med Res Rev 1996;1:87-109.
Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation.
She and her colleagues had previously demonstrated that levels of maternal serum interleukin 6 increase before the onset of clinical evidence of infection in PPROM patients who subsequently develop funisitis.
Interleukin 6 gene -174 G>C and -572G>C promoter polymorphism are strong predictors of plasma interleukin 6 levels after coronary artery surgery.
Determination of the presence of interleukin 6 in bile after orthotopic liver transplantation.
Increase of interleukin 6 serum level preceding fever in granulocytopenia and correlation with death from sepsis.