IL32

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IL32

A gene on chromosome 16p13.3 that encodes interleukin-32, a cytokine which may play a role in innate and adaptive immune responses. It induces other cytokines, including TNFA/TNF-alpha and IL8, and activates the NF-kappa-B and p38 MAPK signal pathways.
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References in periodicals archive ?
One of the most intriguing among numerous cytokines that has role in both hallmarks of cancer is recently described interleukin 32. IL-32 induces the production of proinflammatory cytokines and also directly affects the development and maturation of specific immune cells [17,18].
Park, "Interleukin 32, inflammation and cancer," Pharmacology & Therapeutics, vol.
Joosten, "Interleukin 32: a novel player in the control of infectious diseases," Journal of Leukocyte Biology, vol.
Joosten, "Interleukin 32 (IL-32) contains a typical a-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1," The Journal of Biological Chemistry, vol.