IL31

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IL31

A gene on chromosome 12q24.31 that encodes interleukin-31, an immunomodulatory cytokine which activates STAT3, and possibly STAT1 and STAT5, through the IL31 receptor, which is composed of a heterodimer of IL31RA and OSMR. IL31 may play a role in skin immunity.
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References in periodicals archive ?
Ess et al., "Prerequisites for functional interleukin 31 signaling and its feedback regulation by suppressor of cytokine signaling 3 (SOCS3)," The Journal of Biological Chemistry, vol.
Werfel, "Functional effects of interleukin 31 in human primary keratinocytes," Allergy: European Journal of Allergy and Clinical Immunology, vol.
Hammond et al., "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice," Nature Immunology, vol.