IL27

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IL27

A gene on chromosome 16p11 that encodes interleukin-27, a pro- and anti-inflammatory cytokine that regulates T-helper cell development, suppresses T-cell proliferation, stimulates cytotoxic T-cell activity, induces isotype switching in B-cells, and which has diverse effects on innate immune cells. Its target cells include CD4 T-helper cells, which can differentiate in types 1 and 2 effector cells (TH1 and TH2), and IL17-producing helper T-cells (TH17); it drives rapid clonal expansion of naïve CD4 T-cells. It strongly synergises with IL12 to trigger interferon-gamma production by naïve CD4 T-cells and binds to the cytokine receptor WSX-1/TCCR, which appears to be required for IL27-mediated signal transduction. IL27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It also has antitumour and antiangiogenic activity, with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL27 is also a less preferred gene symbol for what is now designated as IL17D, see there.
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References in periodicals archive ?
The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression.
Recently, Wang et al .[4] proposed that accurate differentiating diagnosis is essential for choosing treatment for exudative pleural effusions and exploring diagnostic accuracy of interleukin 27 for TPE.
Clinical implications of the interleukin 27 serum level in breast cancer.
Wilson et al., "Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system," Nature Immunology, vol.
Galle et al., "Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27," Journal of Experimental Medicine, vol.
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.
Interleukin 27 signaling pathways in regulation of immune and autoimmune responses.
Two studies published in the journal Nature Immunology highlight the role of interleukin 27 (IL-27) in the brain.
Yamamoto-Furusho, "Interleukin 27 is up-regulated in patients with active inflammatory bowel disease," Immunologic Research, vol.
Yi et al., "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells," Nature Immunology, vol.
Miyazaki, "Interleukin 27: a double-edged sword for offense and defense," Journal of Leukocyte Biology, vol.
White et al., "The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression," Intensive Care Medicine, vol.