IL26

(redirected from Interleukin 26)
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IL26

A gene on chromosome 12q15 that encodes a protein belonging to the IL10 family of cytokines thought to have a pro-inflammatory role in mucosal immunity; it is inhibited by heparin. IL26:
• Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT;
• Induces expression of SOCS3, TNF-alpha and IL-8;
• Induces secretion of IL-8 and IL-10 and surface expression of ICAM1; and
• Decreases proliferation of intestinal epithelial cells.

Molecular pathology
IL26 may play a role in inflammatory bowel disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15 that play an important role in inflammation.
According to them, nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15.