IL22

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IL22

A gene on chromosome 12q15 that encodes interleukin-22, a cytokine which plays an uncertain role in the inflammatory response. Il22 is also a less preferred gene symbol for what is now designated as IL17D, see there.
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Absence of interleukin 22 affects the oral microbiota and the progression of induced periapical lesions in murine teeth.
Liu et al., "Interleukin 22 promotes blood pressure elevation and endothelial dysfunction in angiotensin II-treated mice," Journal of the American Heart Association, vol.
In addition, currently, almost all the IL-22 used in rodent PHx models is recombinant human interleukin 22 (rh-IL-22).
(2011) Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma.
Sallusto, "Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells," Nature Immunology, vol.
Li et al., "Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma," Asian Pacific Journal of Allergy and Immunology, vol.
Nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15 that play an important role in inflammation.
Dantas et al., "Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity," The Journal of Rheumatology, vol.
Spits, "Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells," Nature Immunology, vol.
According to them, nearby genes implicated as possibly playing a role in ulcerative colitis include the ring finger protein 186 (RNF186), OTU domain containing 3 (OTUD3), and phospholipase A2, group IIE (PLA2G2E) - genes on chromosome 1p36, and the interferon, gamma (IFNG), interleukin 26 (IL26), and interleukin 22 (IL22) genes on chromosome 12q15.
Liu et al., "Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8," Clinical Immunology, vol.
Fan et al., "Interleukin 22 ameliorated renal injury and fibrosis in diabetic nephropathy though inhibition of NLRP3 inflammasome activation," Cell Death & Disease, vol.