IL21

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IL21

A gene on chromosome 4q26-q27 that encodes IL-21, a cytokine with immunoregulatory activity that may promote the transition between innate and adaptive immunity. IL21 induces the production of IgG1 and IgG3 in B cells, and may play a role in proliferation and maturation of natural killer cells in synergy with IL15. It is also a less preferred gene symbol for what is now designated as IL17C (see there), as well as IL22 (see there).
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References in periodicals archive ?
Nelson et al., "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function," Nature, vol.
Fina et al., "Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21," Gut, vol.
[T.sub.FH] cells primarily exert their function through the secretion of interleukin 21 (IL-21).
Interleukin 21 (IL-21) has a pleiotropic effect on inflammation regulation.
Expression of interleukin 21 and interleukin 21 receptor in muscle tissues of patients with dermatomyositis and polymyositis
The signaling activation of Th17 induces the production of interleukin 17 (IL-17), interleukin 21 (IL-21) and interleukin 22 (IL-22).
[41] described a new subset of follicular helper T (Tfh) cells and interleukin 21 (IL-21), which regulate the development of antigen-specific B-cell immunity, present in human autoimmune thyroid diseases (AITD) (as Graves' disease (GD) and HT).
Higher frequency of peripheral blood interleukin 21 positive follicular helper Tcells in patients with ankylosing spondylitis.
Abbreviations IL-21: Interleukin 21 IL-21R: Interleukin 21 receptor TNF-[alpha]: Tumour Necrosis Factor alpha IL-1[beta]: Interleukin 1 beta MRI: Magnetic resonance imaging.
30 September 2010 - US-based biopharmaceutical company ZymoGenetics Inc (NASDAQ: ZGEN) yesterday announced positive survival data from a Phase IIa clinical trial in metastatic melanoma with recombinant Interleukin 21 (IL-21) as a single agent.
IRF-4-binding protein inhibits interleukin 17 and interleukin 21 production by controlling the activity of IRF-4 transcription factor.