Aevi Genomic Medicine announced that it has obtained the right to exercise an exclusive global license for MEDI2338, a Phase 2-ready fully human monoclonal antibody that targets interleukin 18
. The company plans to initially develop MEDI2338 for adult onset Still's disease, a serious rare and orphan rheumatological disease with no currently approved biologic therapies in the US.
Serum interleukin 18
and interleukin 18
binding protein in rheumatoid arthritis.
stimulates HIV type 1 in monocytic cells.
Overview of interleukin 18
; more than an interferon gama inducing factor.
Serum interleukin 17 and interleukin 18
levels in familial Mediterranean fever.
Interleukin 1 and interleukin 18
as mediators of inflammation and the aging process.
Detection of the interleukin 18
family in rat brain by RT-PCR.
gene promoter polymorphism: a link between hypertension and prehospital sudden cardiac death: the Helsinki Sudden Death Study.
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Mansfield et al., "Interleukin 18
induces angiogenesis in vitro and in vivo via Src and Jnk kinases," Annals of the Rheumatic Diseases, vol.
has promise as a molecular biomarker for prognosis prediction.
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in the heart," Shock, vol.