IL18

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IL18

A gene on chromosome 11q22.2-q22.3 that encodes IL-18, a proinflammatory cytokine that increases natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
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References in periodicals archive ?
Aevi Genomic Medicine announced that it has obtained the right to exercise an exclusive global license for MEDI2338, a Phase 2-ready fully human monoclonal antibody that targets interleukin 18. The company plans to initially develop MEDI2338 for adult onset Still's disease, a serious rare and orphan rheumatological disease with no currently approved biologic therapies in the US.
Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis.
Interleukin 18 stimulates HIV type 1 in monocytic cells.
Overview of interleukin 18; more than an interferon gama inducing factor.
Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process.
Detection of the interleukin 18 family in rat brain by RT-PCR.
Interleukin 18 gene promoter polymorphism: a link between hypertension and prehospital sudden cardiac death: the Helsinki Sudden Death Study.
Kurimoto, "Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both," Clinical Immunology and Immunopathology, vol.
Mansfield et al., "Interleukin 18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases," Annals of the Rheumatic Diseases, vol.
Interleukin 18 has promise as a molecular biomarker for prognosis prediction.