IL17A

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IL17A

A gene on chromosome 6p12 that encodes interleukin-17A, a proinflammatory cytokine produced by activated T cells which regulates NF-kappaB and mitogen-activated protein kinases. It upregulates IL6 and cyclooxygenase-2 and increases nitric oxide production.

Molecular pathology
IL17A is overexpressed in rheumatoid arthritis, psoriasis and multiple sclerosis.
References in periodicals archive ?
XCUR17 is an SNA drug targeted to mRNA encoding interleukin 17 receptor alpha, or IL-17RA.
Suraci et al., "Enhanced expression of indoleamine 2, 3-dioxygenase in Helicobacter pylori-infected human gastric mucosa modulates Th1/Th2 pathway and interleukin 17 production," Helicobacter, vol.
Indicator Reagent set Manufacturer Measurement range Interleukin 17 Human IL-17A eBioscience, 0.5-100.0 (IL-17A) Platinum ELISA USA pg/ml Transforming TGF-[[beta].sub.1]- eBioscience, 31.250-2000 growth mU/ml USA pg/ml factor-[beta] (TGF-[[beta].
As such, it is possible that interleukin 17 blockade may contribute to a shift to the T-helper 1 cell-mediated development of GA.
Fountain et al., "Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis," The Journal of Experimental Medicine, vol.
Interleukin 17 (IL-17) is a common denominator of various inflammatory diseases and has a crucial role in the pathogenesis of PsA and psoriasis.
Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis.
Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2.
* Markers of inflammation in the blood (interleukin 17 and Activin A) were significantly reduced in the MPC-treated group compared with saline-treated controls over the two-week study period
So, "Effect of interleukin 17 on proteoglycan degradation in murine knee joints," Annals of the Rheumatic Diseases, vol.
We evaluated the following pro-inflammatory cytokines: interleukin 1 b (IL-1[beta]), interleukin 2 (IL-2), IL 2 receptor (IL-2R), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 12 (IL-12), interleukin 15 (IL-15), interleukin 17 (IL-17), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon [alpha] (IFN-[alpha]), interferon [gamma] (IFN-[gamma]), monokine induced by IFN-[gamma] (MIG), inducible protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), macrophage inflammatory protein-1[alpha] (MIP-1-[alpha]), macrophage inflammatory protein-1[beta] (MIP-1-[beta]), and tumor necrosis factor [alpha] (TNF-[alpha]).