IL16

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IL16

A gene on chromosome 15q26.3 that encodes interleukin-16, a pleiotropic cytokine that acts as a chemoattractant, a modulator of T-cell activation, and an inhibitor of HIV replication. IL-16 stimulates a migratory response in CD4+ T cells, monocytes and eosinophils; primes CD4+ T-cells for IL-2 and IL-15 responsiveness; and induces T-cell expression of IL-2 receptor.
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References in periodicals archive ?
Cruikshank, "Interleukin 16 and its function as a CD4 ligand," Immunology Today, vol.
Templin et al., "Role of interleukin 16 in multiple myeloma," Journal of the National Cancer Institute, vol.
Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population.
Assignment of human interleukin 16 (IL16)to chromosome 15q26.3 by radiation hybrid mapping.Cytogenet Cell Genet.
Tuzova et al., "A homologous form of human interleukin 16 is implicated in microglia recruitment following nervous system injury in leech Hirudo medicinalis," GLIA, vol.