Interleukin 13 appears to be a potential central mediator of fibrosis in a variety of models and is found upstream of TGF-[beta]1, a well-known mediator of pulmonary fibrosis.
Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung.
Currently, Targepeutics' three pharmaceutical platforms are Genetically Engineered Interleukin 13
(IL- 13), Immunotherapy (applications in cancer and asthma), and Anti-tumor Progression (targeting growth and ability of solid tumors to create new blood vessels).
The contract has been signed for Demira to receive exclusive rights to lebrikizumab, a monoclonal antibody targeting interleukin 13
(IL-13), for atopic dermatitis and all other indications.
Abbreviations IL-4: Interleukin 4 IL-13: Interleukin 13
IL-10: Interleukin 10 IL-6: Interleukin 6 IL-17A: Interleukin 17A TNF-[alpha]: Tumor necrosis factor alpha IFN-[gamma]: Interferon gamma TGF-[beta]: Transforming growth factor beta IL-23: Interleukin 23 Treg: Regulatory T cells Teff: Effector T cells T-bet: T cell-specific T-box transcription factor GATA-3: GATA binding protein 3 Foxp3: Forkhead box P3 ROR-[gamma]t: RAR-related orphan receptor gamma Th1: T helper type 1 cells Th2: T helper type 2 cells Th17: T helper type 17 cells CD4: Cluster of differentiation 4 receptors CD19: Cluster of differentiation 19 receptors GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.
"Using these mice, we found that ILC2 cells were the major population in the skin that produced interleukin 13
, a molecule that has been linked to a number of allergic diseases, including eczema." Roediger said.
(23,37-39) Interleukin 13
regulates the humoral response by driving the proliferation and survival of B cells and triggering immunoglobulin class switching.
Reinisch, "Interleukin 13
and its role in gut defence and inflammation," Gut, vol.
IL-13ra1 is a receptor chain mediating the action of interleukin 13
(IL-13) and interleukin 4 (IL-4), two cytokines investigated for their role as mediators of allergic reactions and for their anti-inflammatory action.
The studies that NeoPharm has performed in animals and in ex-vivo human tissue have shown that the receptors for interleukin 13
(IL13) are significantly over-expressed in pulmonary fibroblasts.