interleukin-12

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in·ter·leu·kin-12

(in'tĕr-lū'kin),
A cytokine derived from B lymphocytes and macrophages that induces γ-interferon (IFNγ) gene expression and IL-2 in T lymphocytes and natural killer cells and down-regulates Th2 cytokines.

in·ter·leu·kin-12

(in'tĕr-lū'kin)
A cytokine derived from B lymphocytes, T lymphocytes, and macrophages that induces interferon-γ gene expression in T lymphocytes and natural killer cells.

interleukin-12

A CYTOKINE produced by T LYMPHOCYTES that inactivates natural killer cells.
References in periodicals archive ?
Ortaldo et al., "Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes," Proceedings of the National Academy of Sciences of the United States of America, vol.
Interleukin 12 (IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease.
Lozonschi et al., "Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12," Cancer Research, vol.
In vitro analysis demonstrated that LMS is synergistic with interleukin 12 in the induction of a Th1 cytokine response at very low concentrations (1microM).
Murray, "Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12," Journal of Experimental Medicine, vol.
Ustekinumab, which is approved to treat adults with moderate to severe plaque psoriasis, and the investigational psoriasis drug briakinumab inhibit interleukin 12 (IL-12) and IL-23 proteins linked to inflammation.
The drug was developed to inhibit elements of the body's immune system, Interleukin 12 and Interleukin 23.
(1) One of the proteins investigated was Interleukin 12 (IL-12).
"The molecule attacks, binds to, and inactivates interleukin 12 and 23.
Cytokine mRNA expression in leprosy: a possible role for interferon g and interleukin 12 in reactions (RR and ENL).
Low penetrance, broad resistance, and favourable outcome of interleukin 12 receptor [beta] 1 deficiency: medical and immunogical implications.