Ortaldo et al., "Interleukin 12
induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes," Proceedings of the National Academy of Sciences of the United States of America, vol.
(IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease.
Lozonschi et al., "Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12
," Cancer Research, vol.
a key immunoregulatory cytokine in infection applications.
In vitro analysis demonstrated that LMS is synergistic with interleukin 12
in the induction of a Th1 cytokine response at very low concentrations (1microM).
Murray, "Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
," Journal of Experimental Medicine, vol.
Ustekinumab, which is approved to treat adults with moderate to severe plaque psoriasis, and the investigational psoriasis drug briakinumab inhibit interleukin 12
(IL-12) and IL-23 proteins linked to inflammation.
The drug was developed to inhibit elements of the body's immune system, Interleukin 12
and Interleukin 23.
(1) One of the proteins investigated was Interleukin 12
"The molecule attacks, binds to, and inactivates interleukin 12
Cytokine mRNA expression in leprosy: a possible role for interferon g and interleukin 12
in reactions (RR and ENL).
Low penetrance, broad resistance, and favourable outcome of interleukin 12
receptor [beta] 1 deficiency: medical and immunogical implications.