interleukin-12

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in·ter·leu·kin-12

(in'tĕr-lū'kin),

A cytokine derived from B lymphocytes and macrophages that induces γ-interferon (IFNγ) gene expression and IL-2 in T lymphocytes and natural killer cells and down-regulates Th₂ cytokines.

Farlex Partner Medical Dictionary © Farlex 2012

in·ter·leu·kin-12

(in'tĕr-lū'kin)

A cytokine derived from B lymphocytes, T lymphocytes, and macrophages that induces interferon-γ gene expression in T lymphocytes and natural killer cells.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

interleukin-12

A CYTOKINE produced by T LYMPHOCYTES that inactivates natural killer cells.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive ?

Ortaldo et al., "Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes," Proceedings of the National Academy of Sciences of the United States of America, vol.

Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis

Interleukin 12 (IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease.

Efficacy of different durations of intravenous methylprednisolone treatment in relapses of multiple sclerosis

Lozonschi et al., "Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12," Cancer Research, vol.

Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma

Interleukin 12 a key immunoregulatory cytokine in infection applications.

Interleukin-12 gene adjuvant increases the immunogenicity of virus-like particles of human papillomavirus type 16 regional variant strain

In vitro analysis demonstrated that LMS is synergistic with interleukin 12 in the induction of a Th1 cytokine response at very low concentrations (1microM).

Investigating the role of immunomodulation for colon cancer prevention: results of an in vivo dose escalation trial of levamisole with immunologic endpoints

Murray, "Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12," Journal of Experimental Medicine, vol.

PPAR[gamma] agonists in adaptive immunity: what do immune disorders and their models have to tell us?

Ustekinumab, which is approved to treat adults with moderate to severe plaque psoriasis, and the investigational psoriasis drug briakinumab inhibit interleukin 12 (IL-12) and IL-23 proteins linked to inflammation.

Biologics may increase cardiovascular risk in psoriasis

The drug was developed to inhibit elements of the body's immune system, Interleukin 12 and Interleukin 23.

MONEY BRIEFS

(1) One of the proteins investigated was Interleukin 12 (IL-12).

The adoption of SPR in drug discovery and development

"The molecule attacks, binds to, and inactivates interleukin 12 and 23.

Ustekinumab aids long-term control of psoriasis

Cytokine mRNA expression in leprosy: a possible role for interferon g and interleukin 12 in reactions (RR and ENL).

Increased level of urinary nitric oxide metabolites in leprosy patients during Type 2 reactions and decreased after antireactional therapy

Low penetrance, broad resistance, and favourable outcome of interleukin 12 receptor [beta] 1 deficiency: medical and immunogical implications.