IL10

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IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
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References in periodicals archive ?
WiseGuyReports.Com Publish a New Market Research Report On -" Interleukin 10 Industry - Treatment, Outlook, Analysis, Research, Review to 2023".
Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age.
Horvat, "Pathologic patterns of interleukin 10 expression - a review," Biochemia Medica, vol.
Periodontal disease/exp or periodontitis/exp or periodontics/exp or periodontal disease: ab, ti or periodontitis: ab, ti or periodontal pocket: ab, ti or periodontal tissue: ab, ti and Interleukin 10/exp or Interleukin 10: ab, ti or IL10: ab, ti or rs1800872: ab, ti and DNA polymorphism/ exp or genetic variability/exp or polymorphism: ab, ti or polymorphisms: ab, ti or genetic variation: ab, ti.
Although previous studies in healthy populations have shown changes in CD40 and CD45 levels, interleukin 1[beta] (IL-1 [beta]), interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 10 (IL-10), Tumor necrosis factor alpha (TNF-[alpha]), and interferon gamma (IFN-[gamma]) levels remain constant (3).
Horvat, "Pathologic patterns of interleukin 10 expression--a review," Biochemical Medicine, vol.
Kim et al., "Interleukin 10 acts on regulatory t cells to maintain expression of the transcription factor foxp3 and suppressive function in mice with colitis," Nature Immunology, vol.
The report provides comprehensive information on the Interleukin 10 (Cytokine Synthesis Inhibitory Factor or CISF or IL10) , targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Sartor, "Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers," Gut, vol.
Abbreviations BMDC: Bone-marrow-derived dendritic cells Fc[gamma]R: Fc gamma receptor FCS: Fetal calf serum rmGM-CSF: Recombinant murine granulocyte-macrophage colony-stimulating factor IL-10: Interleukin 10 IL-12p70: Interleukin 12p70 IVIG: Intravenous immunoglobulin LPS: Lipopolysaccharide TLR4: Toll-like receptor 4.
Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1/CC chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production.