interferons


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interferons

A considerable range of antiviral protein substances produced by cells that have been invaded by viruses. Interferons are released by such cells and provide protection to other cells liable to be invaded, not only by the original virus, but also by any other infecting organism. They also modify various cell-regulating mechanisms and slow down the growth of cancers. Alpha-interferons are derived from various white cells of the immune system; interferon beta from fibroblasts; and interferon gamma from T LYMPHOCYTES (T cells). Interferons can be produced in quantity by GENETIC ENGINEERING methods and are effective in the treatment of a variety of virus-associated conditions including Kaposi's sarcoma, the common cold, herpes simplex infections, genital warts and an uncommon form of leukaemia, hairy cell leukaemia.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
With the exception of the abortifacient effects in animals, studies have not documented teratogenicity or other fetal harm in animals or humans receiving interferons. However, the potential for long-term effects in a child exposed to interferons in utero is unknown.
Headquartered in Cambridge, MA, the company's revenues are generated from international sales of AVONEX (Interferon beta-1a) for treatment of relapsing forms of multiple sclerosis, and from the worldwide sales by licensees of a number of products, including alpha interferon and hepatitis B vaccines and diagnostic products.
Research thus far has concentrated on the drugs' enhancement of interferon and natural killer cell activity, which Carter calls the "fighting couple" of the immune system.
Material and Methods: The study included 15 co-infected patients of hepatitis B and C resistant to interferon therapy and 15 healthy individuals as control.
pegylated interferons conventional interferons alpha2a and 2b along with ribavirin was the 4-6 standard treatment for chronic hepatic C patients.
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays.
(Santiago, Chile) to distribute Viragen's natural human alpha interferon, Multiferon, exclusively in Chile.
Patients and Methods: The study after approved by institute's ethics committee was conducted on 15 HCV infected patients who were non responder to interferon therapy and 5 controls responder to interferon therapy.
We have demonstrated that the nonstructural protein 1 (NS1) of influenza viruses has interferon antagonist activity (16).
Although interferons are proteins and are probably digested if taken orally, it's best to avoid them during nursing because of the potential for serious toxicity in the infant.
My wife has just been prescribed interferon for her Multiple Sclerosis.What do I need to know about it?
They are representative compounds from major antiviral pharmacologic classes that are currently commercially available: nucleoside analogs, interferons, protease inhibitors, reverse transcriptase inhibitors and neuraminidase inhibitors.