interferons


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interferons

A considerable range of antiviral protein substances produced by cells that have been invaded by viruses. Interferons are released by such cells and provide protection to other cells liable to be invaded, not only by the original virus, but also by any other infecting organism. They also modify various cell-regulating mechanisms and slow down the growth of cancers. Alpha-interferons are derived from various white cells of the immune system; interferon beta from fibroblasts; and interferon gamma from T LYMPHOCYTES (T cells). Interferons can be produced in quantity by GENETIC ENGINEERING methods and are effective in the treatment of a variety of virus-associated conditions including Kaposi's sarcoma, the common cold, herpes simplex infections, genital warts and an uncommon form of leukaemia, hairy cell leukaemia.
References in periodicals archive ?
Pegylated interferon remains the first line treatment for patients with hepatitis D virus and more than one year therapy may be necessary.
They were divided in to two groups, one who used interferon and the other who did not.
Studies that have directly compared interferon alpha-2a and interferon alpha-2b have been "limited in sample size or scope" and have arrived at disparate conclusions, the investigators said.
Prevention of lethal respiratory vaccinia infections in mice with interferon (IFN)-a and IFN-g.
With all interferons, animals given large doses have had abortions, but this does not appear to occur with doses used clinically.
Plantation, FL; 954-233-8746) announced it has been granted United States Patent 6,350,589 from the United States Patent and Trademark Office for a process relating to the manufacture of human natural alpha interferon from human white blood cells.
Headquartered in Cambridge, MA, the company's revenues are generated from international sales of AVONEX (Interferon beta-1a) for treatment of relapsing forms of multiple sclerosis, and from the worldwide sales by licensees of a number of products, including alpha interferon and hepatitis B vaccines and diagnostic products.
Research thus far has concentrated on the drugs' enhancement of interferon and natural killer cell activity, which Carter calls the "fighting couple" of the immune system.
Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.
This seeming dead end led him to study the then newly identified interferon molecules, which are produced by immune-system cells.