IRF6

(redirected from Interferon regulatory factor-1)

IRF6

A gene on chromosome 1q32.3-q41 that encodes a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such as virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity. IRF6 appears to be a transcription activator.

Molecular pathology
IRF6 mutations are linked to non-syndromic orofacial cleft type 6, popliteal pterygium syndrome and van der Woude syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Interferon regulatory factor-1 as a positive regulator for high glucose-induced proliferation of vascular smooth muscle cells.
Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells.
The membranes were incubated with primary antibodies, including anti-T-bet/Tbx21antibody (1:1000), anti-Fas antibody (1: 1000) (Abcam, Cambridge, MA, USA), and anti-mouse-caspase-3, anti-mouse-cleaved caspase-3 antibody, anti-mouse-eukaryotic initiation factor 2 (eIF2) a (D7D3), anti-mouse-phospho-eIF2a (Ser51) (D9G8), anti-mouse-Fyn, anti-mouse interferon regulatory factor-1 (IRF-1), anti-mouse-signal transducer and activator of transcription (Stat) 1, and anti-mouse-Stat3 rabbit monoclonal antibodies (1: 1000, CST, Boston, MA, USA) and incubated with horseradish peroxidase-conjugated secondary antibody (CST).
Rockett et al., "Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection," Genes & Immunity, vol.
IFN- a activates the transcription factor IRF-1 (interferon regulatory factor-1), which also binds to elements in the NOS promoter [41,42].
IDO1 is induced by IFN-[gamma]-mediated effects of the signal transducer and activator of transcription 1[alpha] (STAT1[alpha]) and interferon regulatory factor-1 (IRF-1).
Wietzerbin, "Triggering of the human interleukin-6 gene by interferon-[gamma] and tumor necrosis factor-a in monocytic cells involves cooperation between interferon regulatory factor-1, NF[kappa]B, and Sp1 transcription factors," The Journal of Biological Chemistry, vol.

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