IL28B

(redirected from Interferon lambda-3)

IL28B

A gene on chromosome 19q13.13 that encodes interleukin-28B, an immunomodulatory cytokine which upregulates MHC class-I antigen expression. It has potent antiviral activity and has antitumour activity. IL28B is a ligand for the heterodimeric class-II cytokine receptor composed of IL10RB and IL28RA, which is thought to act via the JAK-STAT pathway. Difference between the two isoforms of IL28 (IL28A and IL28B) remains unclear.
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- IL28B genotyping: IL28B (recently known as interferon lambda-3) has three genotypes: CC, CT and TT.

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