interferon gamma


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Related to interferon gamma: interferon alpha

in·ter·fer·on gam·ma

interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation; only one gene codes for gamma interferon. interferon γ behaves like a biologic response modifies and is highly immunoregulatory.

interferon gamma

IFNG

A gene on chromosome 12q14 that encodes a soluble cytokine belonging to the type-II interferon family that has antiviral, immunoregulatory and anti-tumour properties, and is a potent macrophage activator. It is produced by lymphocytes activated by specific antigens or mitogens.

Molecular pathology
Defects in IFNG is associated with increased susceptibility to aplastic anaemia in Caucasians.

interferon gamma

IFN-γ A 21-25 kD glycoprotein lymphokine encoded on chromosome 12q and produced by activated T and NK cells; IFN-γ is antiviral, regulates class II MHC antigen expression, Fc receptors and immunoglobulin production and class switching, activates monocyte cytotoxicity and enhances NK cell activity; IFN-γ is ↓ in IgA deficiency, lymphoma, CLL, infections–eg, CMV, EBV, rubella, lepromatous leprosy, TB, SLE, rheumatoid arthritis, sickle cell anemia, post-transplantation Indications Recombinant IFN-γ is used to treat condylomata acuminata, CLL, Hodgkin's disease, mycosis fungoides, rheumatoid arthritis, and possibly leprosy, TB, nontuberculous mycobacterial infections, toxoplasmosis, chronic granulomatous disease–to prevent infections; IFN-γ suppresses collagen synthesis by fibroblasts, ↓ the size of keloids, causing a local ↑ in inflammatory cells and mucin production, and may be of use in controlling abnormal fibrosing conditions Side effects Acute renal failure, rash, headache, chills

in·ter·fer·on gam·ma

(intĕr-fēron gamă)
That interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.
Synonym(s): antigen interferon, immune interferon.

interferon gamma

An INTERFERON used as an antiviral drug. A brand name is Immukin.

in·ter·fer·on gam·ma

(intĕr-fēron gamă)
Interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.
References in periodicals archive ?
Effect of immunosuppressive therapy on interferon gamma release assay for latent tuberculosis screening in patients with autoimmune diseases: a systematic review and meta-analysis.
Beebe et al., "Interferon gamma and tumor necrosis factor are not essential parameters of CD4(+) T-cell responses for vaccine control of tuberculosis," Journal of Infectious Diseases, vol.
Nacheva, "Production of aggregation prone human interferon gamma and its mutant in highly soluble and biologically active form by SUMO fusion technology," Protein Expression and Purification, vol.
Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts.
In lab tests of devil tumor cells, the researchers were able to turn MHC genes back on with a dose of either an antifungal drug called Trichostatin A--known to affect gene activity--or an immune chemical called interferon gamma. Dogs infected with a contagious cancer called canine transmissible venereal tumor keep the nonfatal cancer in check partly by making interferon gamma.
Latent TB Infection (LTBI) is diagnosed when the patient has evidence of TB infection either by positive Mantoux Tuberculin skin test (TST) or more recently by a positive interferon gamma release assays (IGRAs) with no clinical or radiological evidence for active disease.
Keywords: Interferon gamma, Interferon alpha, Ribavirin, Hepatitis C, Non responders, Relapsers (JPMA 62: 338; 2012).
An immunohistochemical study was undertaken to understand the pathological consequences of the T helper response to unresolving chronic infection, the distribution of CD4, CD8, CD25, interleukin (IL)2, interferon gamma (IFN[gamma]), IL10, transforming growth factor (TGF) [beta] and fork head Box P3 (FOXP3) in the inflammatory cell infiltrates in three types of cervical lesions caused by HPV viz.
It detects in vitro cell-mediated immune responses to TB infection by quantifying the amount of interferon gamma (IFN-[gamma]) released in the plasma of whole blood incubated overnight with mixtures of overlapping peptides spanning the sequence of the early secretory antigenic target 6-kDa (ESAT-6) protein and the culture filtrate protein 10kDa (CFP-10).
Binding of mAb L9.7 to surface LLT1 induced interferon gamma production in YT, a human NK cell line, as well as in resting and IL-2 activated NK cells, without modulating cytotoxicity.
In VL, susceptibility is associated with an inability to produce a macrophage--stimulating cytokine profile (Th1 profile), including interferon gamma (IFN-gamma]) and interleukin--12 (IL-12); instead, production of immunosuppressive cytokines, such as interleukin 10 (IL-10), (Th2 profile) is observed (10).
In May 2008, Exir began producing hepatitis C treatment interferon gamma under the brand name Gamma Immunex.

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