IRF3

(redirected from Interferon Regulatory Factor 3)
Also found in: Acronyms.

IRF3

A gene on chromosome 19q13.3-q13.4 that encodes a member of the interferon regulatory transcription factor (IRF) family. IRF3 is inactive in the cytoplasm, but after serine/threonine phosphorylation forms a complex with CREBBP; the IRF3/CREBBP complex translocates to the nucleus and activates transcription of interferons alpha and beta, as well as interferon-induced genes.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Hiscott, "Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription," Molecular and Cellular Biology, vol.
Interferon-regulatory factors determine macrophage phenotype polarization
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