Loukas, "Exploiting helminth-host interactomes
through big data," Trends in Parasitology, vol.
SAMs can also interact with nonadhesion molecules like receptors, channels, and secreted factors in the synaptic cleft working to recruit and organize synaptic protein networks (or "synaptic interactomes
Groen, "Forward individualized medicine from personal genomes to interactomes
," Frontiers in Physiology, vol.
Among the topics are polysaccharide based biomaterials, biopolymers in the prevention of dental erosion, biomedical applications of recombinant proteins and derived polypeptides, high-order perturbation theory models of drug-target interactomes
for proteins expressed on networks of hippocampus brain region of Alzheimer disease patients, and the dynamic analysis of backbone-hydrogen-bond propensity for protein binding and drug design.
The research findings described in this media release can be found in the scientific journal Molecular Cell, under the title, "In Vivo Mapping of Eukaryotic RNA Interactomes
Reveals Principles of Higher-Order Organization and Regulation" by Jong Ghut Ashley Aw(1),(5), Yang Shen(2),(5), Andreas Wilm(2),(5), Miao Sun(2), Xin Ni Lim(1), Kum-Loong Boon(1), Sidika Tapsin(1), Yun-Shen Chan(1), Cheng-Peow Tan(1), Adelene Y.L.
Faure, "Autophagy and RNA virus interactomes
reveal IRGM as a common target," Autophagy, vol.
To further understand the downstream pathways through which Notch3 and Notch4 mediate ozone-induced lung inflammation, we used genome-wide transcriptome analysis to identify candidate gene transcripts and interactomes
. ANOVA modeling of the data identified few differentially expressed genes between WT and knockout mice after air exposure (see Supplemental Material, Table S2).
Indeed, recent comparisons of the SOX2 interactomes
in ES cells before and after the initiation of differentiation have shown that this protein's interactions change dramatically within 24 hours .
Systems biology approaches and tools for analysis of interactomes
and multi-target drugs.
The extensive host/pathogen interactomes
of numerous viruses, bacteria, and parasites no doubt result from this homology which enables pathogen proteins to mimic particular motifs within their human counterparts and to compete for their usual binding partners.
See Mark Gerstein et al., Integrating Interactomes
, 295 SCIENCE 284, 285 (2002).