intention to treat

intention to treat

In clinical trials, the principle that holds that the effect of a treatment regimen can be best assessed by evaluating the basis of the intention to treat a subject (i.e., the planned treatment regimen), rather than the actual treatment given. Thus, subjects allocated to a treatment group should be followed, assessed and analysed as members of the treatment group irrespective of their compliance with the planned course of treatment. The principle of intention to treat is meant to prevent bias caused by loss of trial participants, which may reflect non-adherence to the protocol and disrupt baseline equivalence established by random assignment.
References in periodicals archive ?
The Mexican authorities stated their intention to treat the arrangement as precautionary.
The Colombian authorities stated their intention to treat the new arrangement as precautionary and do not intend to draw on it.
The primary efficacy analysis was conducted on an intention to treat basis, testing the dose dependent effects of once daily OCA (10mg, 20mg and 40mg) compared with placebo.
3 per 100 person-years) AIN, anal intraepithelial neoplasia; CI, confidence interval; HPV, human papillomavirus; HR, hazard ratio; ITT, intention to treat analysis; MSM, men who have sex with men; PP, per protocol analysis; qHPV, quadrivalent human papillomavirus vaccine; RCT, randomized controlled trial.
The hospital said that it carried out a full investigation into the incident and apologised to the family, adding that it is "always our intention to treat all deceased patients with the highest levels of dignity and respect".
But Hodgson has confirmed his intention to treat the 20-year-old with kid gloves and has already confirmed Wilshere will not start in the new 50,000-capacity Friends Arena.
The non-inferiority of the fixed-dose regimen was shown in the per protocol analysis and a post hoc modified intention to treat analysis, but not in the prespecified modified intention to treat analysis, where 83.
In the intention to treat analysis, there were 39,601 pregnancies and 138 pregnancy-related deaths in the vitamin A supplementation group (348 deaths per 100,000 pregnancies) compared with 39,234 pregnancies and 148 pregnancy-related deaths in the placebo group (377 per 100,000 pregnancies), (adjusted odds ratio 0.
There is no intention to treat residents of the west Bank who are
He has (sounded his) intention to treat her Aa for free," C Valeriano said.
This chapter is very informative, covering important concepts including intention to treat analysis, subgroup analysis, interactions between subgroups and ethical issues related to research in critical care.
This decision reflects our intention to treat these investments as trading assets so that we can reflect the expected recovery in their prices in our income in future periods.