ILK

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ILK

A gene on chromosome 11p15.4 that encodes a receptor-proximal serine/threonine protein kinase which regulates integrin-mediated signal transduction, possibly by mediating so-called inside-out integrin signalling. ILK is the adhesion protein member of the ILK-PINCH complex, which is a convergence point of the integrin- and growth factor-signalling pathways; it may play a role in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. It is highly expressed in the heart, and less so in the skeletal muscle, pancreas and kidneys.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Yigitbasi et al., "Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer," Molecular Cancer Therapeutics, vol.
Yazici et al., "Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck," Archives of Otolaryngology --Head & Neck Surgery, vol.
Hedley, "Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts," Cancer Research, vol.
Wederell et al., "Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival," Cancer Research, vol.
Fassler, "Integrin-linked kinase at a glance," Journal of Cell Science, vol.
Dedhar, "Integrin-linked kinase: a cancer therapeutic target unique among its ILK," Nature Reviews Cancer, vol.
Dedhar, "Integrin-linked kinase: not so 'pseudo' after all," Oncogene, vol.
Fassler, "Integrin-linked kinase regulates chondrocyte shape and proliferation," EMBO Reports, vol.
Dedhar, "A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells," Oncogene, vol.