integrin


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integrin

(ĭn′tə-grĭn)
n.
Any of a group of transmembrane proteins that bind to certain molecules in the extracellular matrix or on the surface of other cells. They are involved in cell adhesion and motility and in the transmission of signals across the plasma membrane.

integrin

a receptor PROTEIN allowing cells to bind to and respond to the EXTRACELLULAR MATRIX. Integrins are members of a large family of cell adhesion receptors involved in cell-extracellular matrix and cell-cell interactions. see ANOIKIS.
References in periodicals archive ?
The collaboration concentrates on several undisclosed integrin targets and will explore both inhibitors and activators of integrin function.
Additionally, Morphic Therapeutic' scientific founder Tim Springer has developed a unique platform for designing integrin oral inhibitors to block TGF-?
CRT, a molecular chaperone(5), binds to integrin subunits and promotes cell adhesion (Reference document 2).
[13.] Hughes AL (2001) Evolution of the integrin alpha and beta protein families.
The expression and localization of [alpha]4, [beta]1, [alpha]v, and [beta]6 integrin subunits were investigated using flow cytometry and immunofluorescence staining.
Three leukocyte adhesion deficiency (LAD) disorders have been well recognized, caused by genetic defects in Beta 2 integrin family consist of LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), Complement receptor 4 (CD11c/CD18), and (CD11d/CD18).1
Expressions of cytokeratin, vimentin, integrin avfi3, and leukemia inhibitory factor (LIF) proteins were performed by incubating slides of rat uteri with rabbit polyclonal antibodies against cytokeratin, vimentin, integrin avfi3, and LIF overnight at 4[degrees]C.
Immunofluorescence staining was performed as previously described [25] using primary antibodies against integrin-[alpha]2 (mouse, Santa Cruz Biotechnology, sc-74466) and collagen type 1 (rabbit, Abcam, ab34710) as set 1 as well as integrin [alpha]6 (rabbit, Invitrogen, 710201) and laminin-[beta]3 (mouse, Santa Cruz Biotechnology, sc-33178) as set 2 along with Alexa Fluor[R] dye-conjugated anti-rabbit and anti-mouse (Thermo Fisher Scientific) secondary antibodies to detect the expression of the integrin receptors on the surface of the cells in response to the polymer matrices.
Bendeck, "Integrin linked kinase (ILK) expression and function in vascular smooth muscle cells," Cell Adhesion & Migration, vol.