integrase

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integrase

(ĭn′tĕ-grās)
A retroviral enzyme that incorporates DNA derived from the virus into host cell chromosomes. The enzyme is a target for experimental antiretroviral therapies.
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References in periodicals archive ?
It includes a fragment (named R4') inserted into the umuC gene, which is characterized by a phage integrase (ORF38) and a phage integrase family site-specific recombinase (ORF37) and encodes 9 genes from different origins with various functions.
Fragment R4' in pPV989-94 encodes 11 genes that span from the phage integrase (ORF38) to PQQ-dependent catabolism-associated beta-propeller protein (HET-E-1, ORF22) in R4 and is 10.7 kb in length (Figure 2).
There were 9 ORFs predicted in the R4' fragment other than the phage integrase and the site-specific recombinase genes.
However, plasmid pPV989-94 contained a variable region that was a mobile genetic element mediated by the phage integrase and site-specific recombinase, and the region carried genes related to glycometabolism, resistance, and DNA repair.
Three pair primers were used to obtain the converse regions sequence of the three classes integrase genes respectively while the variable region of the integrons were determined with another pair primers.14 Using the internal primers for the class 2 integrase gene amplification reaction to detect the presence of class 2 integron was carried out as previously described.8 All primers are listed in Table-I.
###IntI1F###ACGAGCGCAAGGTTTCGGT###Class 1 integrase gene###565###[14]
###IntI2F###GTGCAACGCATTTTGCAGG###Class 2 integrase gene###403###[14]
###IntI3F###CATTTGTGTTGTGGACGGC###Class 3 integrase gene###717###[14]