Under the growth conditions used by the investigators, a surprisingly, high number of insulin-secreting cells
developed in tissue culture from undifferentiated stem cells, and were shown to secrete high levels of insulin into the growth medium.
Kadimastem is working to develop innovative treatments for diabetes through transplantation of insulin-secreting cells
which were differentiated from human stem cells.
Previous attempts had resulted in insulin-secreting cells
that were immature (more like fetal cells than adult cells), so they didn't work as well.
Baicalein Promoted GSIS in Insulin-Secreting Cells
and Human Islets.
Working with mice, a team of researchers at the Johns Hopkins Children's Center discovered that a protein called EPAC2 - deemed a second-fiddle player up until now - is actually an important regulator of insulin that appears to work by nudging insulin-secreting cells
of the pancreas to ramp up production of the sugar-regulating hormone when the body needs it most.
Researchers have long puzzled over what causes the body to turn against itself in type 1 diabetes, an autoimmune disease that destroys insulin-secreting cells
in the pancreas.
In experiments on mice, the group succeeded in differentiating intestinal cells from a mouse embryo and insulin-secreting cells
. The cells were then transplanted into the abdomen of diabetic mice.
The damage only becomes irreversible years down the road when insulin-secreting cells
in the pancreas die and can't be regrown.Are some people more likely to suffer liver metabolism problems?
LOUIS, Mo., May 10, 2016 -- Signaling a potential new approach to treating diabetes, researchers here and in Massachusetts have produced insulin-secreting cells
from stem cells derived from patients with type 1 diabetes.
Wagner, "Expression of TAU in insulin-secreting cells
and its interaction with the calcium-binding protein secretagogin," Journal of Endocrinology, vol.
Rulifson, currently at the University of Pennsylvania School of Medicine in Philadelphia, and Seung Kim, his collaborator at Stanford, have now discovered a likely candidate: corpora cardiaca (CC) cells, located near insulin-secreting cells
in the Drosophila brain.
TORONTO, Canada, October 16, 2015 -- Researchers last year made significant progress in the quest to generate a fully functional cell type from scratch--one of the key goals of stem cell research and regenerative medicine--by developing a protocol that converts human stem cells into glucose-responsive, insulin-secreting cells
capable of reversing diabetes in mice.