IGF2

(redirected from Insulin-like growth factor ii)
Also found in: Acronyms.

IGF2

A gene on chromosome 11p15.5 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development. It is an imprinted gene and expressed only from the paternal allele.

Molecular pathology
Epigenetic changes at 11p15.5 are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma and Silver-Russell syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
Chen et al., "Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through Gaq and downstream calcineurin signaling in myocardial cells," Endocrinology, vol.
Characterization of 0-glycosylated precursors of insulin-like growth factor II by matrix-assisted laser desorption/ionization mass spectrometry.
Biophysical and biological properties of naturally occurring high molecular weight insulin-like growth factor II variants.
A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis.
Insulin-like growth factor II synthesis and secretion by a leiomyosarcoma with associated hypoglycemia.
Development of a specific radioimmunoassay for E domain containing forms of insulin-like growth factor II. Adv Exp Med Biol 1991;293:45-56.
Expression of insulin-like growth factor II (IGF-II) and histological changes in the thymus and spleen of transgenic mice overexpressing IGF-II.

Full browser ?