IGF1R

(redirected from Insulin-like growth factor I receptor)

IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
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References in periodicals archive ?
Functionally significant insulin-like growth factor I receptor mutations in centenarians.
Heterozygous mutation within a kinase-conserved motif of the insulin-like growth factor I receptor causes intrauterine and postnatal growth retardation.
Insulin-like growth factor I receptor expression and function in fibroblasts from two patients with deletion of the distal long arm of chromosome 15.
Down-regulation of Insulin-like growth factor I receptor and Insulin receptor by siRNA reduce the invasiveness of trophoblast cells: Role of MMP-9.
Baldini et al., "Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells," Clinical Cancer Research, vol.
Manara et al., "Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells" Cancer Gene Therapy, vol.
Oestrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.
Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase and Akt.
(2008) Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.
Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor. Cancer Res 2005; 65 : 3781-7.
Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors," The Biochemical Journal, vol.

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