Functionally significant
insulin-like growth factor I receptor mutations in centenarians.
Heterozygous mutation within a kinase-conserved motif of the insulin-like growth factor I receptor causes intrauterine and postnatal growth retardation.
Insulin-like growth factor I receptor expression and function in fibroblasts from two patients with deletion of the distal long arm of chromosome 15.
Baldini et al., "Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells," Clinical Cancer Research, vol.
Manara et al., "Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells" Cancer Gene Therapy, vol.
Oestrogen signaling via a linear pathway involving
insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.
Antiapoptotic signaling by the
insulin-like growth factor I receptor, phosphatidylinositol 3-kinase and Akt.
(2008)
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.
Tumor development by transgenic expression of a constitutively active
insulin-like growth factor I receptor. Cancer Res 2005; 65 : 3781-7.
Evidence for structural heterogeneity of
insulin-like growth factor I receptors involving hybrids with insulin receptors," The Biochemical Journal, vol.