IGF1R

(redirected from Insulin-like growth factor 1 receptor)
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IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.

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References in periodicals archive ?

During active TED, which can last up to three years, the insulin-like growth factor 1 receptor (IGF-1R) is overexpressed on orbital fibroblasts, resulting in local inflammation and tissue expansion.

During active TED the insulin-like growth factor 1 receptor (IGF-1R) is overexpressed on orbital fibroblasts, resulting in local inflammation and tissue expansion, which can in turn lead to proptosis, or bulging of the eye.

Teprotumumab is a fully human monoclonal antibody and a targeted inhibitor of the insulin-like growth factor 1 receptor (IGF-1R).

Horizon Pharma Presents Results of 48 Week Off-Therapy Follow-Up to the Phase 2 Trial of Teprotumumab

An infant with deletion of the distal long arm of chromosome 15 (q26.1 qter) and loss of insulin-like growth factor 1 receptor gene.

Response to Growth Hormone Treatment in a Patient with InsulinLike Growth Factor 1 Receptor Deletion

Relative gene expression of: a) Growth hormone (gh), b) Insulin-like growth factor 1 (igf-1), c) growth hormone receptor (ghra) and d) Insulin-like growth factor 1 receptor (igf-1ra/b), insulin-like growth factor binding protein 1 (igfbp-1) in the zebrafish larvae small and large body length groups assessment by qPCR.

Comparison of gene expression patterns of key growth genes between different rate growths in zebrafish (Danio rerio) siblings

Accordingly, we also found that insulin-like growth factor 2 receptor (IGF2R), but not insulin-like growth factor 1 receptor (IGF1R), was highly expressed in velvet.

De Novo Characterization of Velvet Skin Transcriptome at the Antlers Tips of Red Deer (Cervus elaphus) and Analysis of Growth Factors and Their Receptors Related to Regeneration

Axelar, a Swedish biotech company, has started a Phase I/II study of AXL1717, an oral insulin-like growth factor 1 receptor pathway inhibitor, in patients with brain tumours in the United States.

Axelar starts Phase I/II study of AXL1717

The insulin-like growth factor 1 receptor (IGF-1R) has been the subject of more than 20 years of research as a potential therapeutic target in ES [2].

Crowley et al., "R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study," Journal of Clinical Oncology, vol.

Insulin-like growth factor 1 receptor as a therapeutic target in Ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature

Functionally significant insulin-like growth factor 1 receptor mutations in centarians.

The role of insulin-like growth factor in longevity

Polymorphism of Insulin-like Growth Factor 1 Receptor Gene in 12 Pig Breeds and Its Relationship with Pig Performance Traits.

Polymorphism of insulin-like growth factor binding protein-4 gene in 17 pig breeds and its relationship with growth traits

Additional studies also showed that NADPH oxidase-derived oxidative products also damaged proteins including insulin-like growth factor 1 receptors located on motor neurons.

Inflammatory enzyme modulates motor neuron damage in amyotrophic lateral sclerosis