IGF1R

(redirected from Insulin-like growth factor 1 receptor)
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IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
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During active TED, which can last up to three years, the insulin-like growth factor 1 receptor (IGF-1R) is overexpressed on orbital fibroblasts, resulting in local inflammation and tissue expansion.
During active TED the insulin-like growth factor 1 receptor (IGF-1R) is overexpressed on orbital fibroblasts, resulting in local inflammation and tissue expansion, which can in turn lead to proptosis, or bulging of the eye.
Teprotumumab is a fully human monoclonal antibody and a targeted inhibitor of the insulin-like growth factor 1 receptor (IGF-1R).
An infant with deletion of the distal long arm of chromosome 15 (q26.1 qter) and loss of insulin-like growth factor 1 receptor gene.
Relative gene expression of: a) Growth hormone (gh), b) Insulin-like growth factor 1 (igf-1), c) growth hormone receptor (ghra) and d) Insulin-like growth factor 1 receptor (igf-1ra/b), insulin-like growth factor binding protein 1 (igfbp-1) in the zebrafish larvae small and large body length groups assessment by qPCR.
Accordingly, we also found that insulin-like growth factor 2 receptor (IGF2R), but not insulin-like growth factor 1 receptor (IGF1R), was highly expressed in velvet.
Axelar, a Swedish biotech company, has started a Phase I/II study of AXL1717, an oral insulin-like growth factor 1 receptor pathway inhibitor, in patients with brain tumours in the United States.
The insulin-like growth factor 1 receptor (IGF-1R) has been the subject of more than 20 years of research as a potential therapeutic target in ES [2].
Crowley et al., "R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study," Journal of Clinical Oncology, vol.
Functionally significant insulin-like growth factor 1 receptor mutations in centarians.
Polymorphism of Insulin-like Growth Factor 1 Receptor Gene in 12 Pig Breeds and Its Relationship with Pig Performance Traits.
Additional studies also showed that NADPH oxidase-derived oxidative products also damaged proteins including insulin-like growth factor 1 receptors located on motor neurons.

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