insulin tolerance test


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insulin tolerance test

,

ITT

A test to determine a patient's hormonal responses to induced hypoglycemia. After 0.1 IU of insulin/kg is given intravenously, blood is drawn at regular intervals to measure serum cortisol in patients with suspected adrenal insufficiency or growth hormone in suspected growth hormone deficiency. The goal of the test is to stress the body with low blood glucose levels (> 40 mg/dl).

CAUTION!

The test should be administered only by experienced professionals in order to reduce the risk of severe hypoglycemic reactions.
References in periodicals archive ?
Intraperitoneal glucose tolerance test (GTT) (a) and insulin tolerance test (ITT) (b) were performed and area under curve (AUC) was measured for the GTT.
At the end of 12 weeks insulin tolerance test (ITT) was performed in all groups.
Response to insulin tolerance test on admission and first control visit MAY 2009 AUGUST 2009 Time (minute) 0.
Once suspected, the definitive diagnosis can be confirmed by laboratory evaluation of adrenocortical function by short synacthen test, insulin tolerance test and metyrapone test13.
Herrmann's study, which was funded by Novo Nordisk, 6 of the 18 head trauma patients with pituitary deficiency had GH deficiency, defined as a GH response of less than 9 [micro]g/L to stimulation with GH releasing hormone plus arginine, and of less than 3 [micro]g/L to the insulin tolerance test (ITT).
This is a very practical issue because inexperienced junior colleagues have aborted an insulin tolerance test (ITT) when the patient was symptomatic and the glucose meter reading was 35 mg/ dL.
The hypothalamic-pituitary-adreno-cortical glucocorticoid axis can be studied during the insulin tolerance test. Cortisol secretion is normally elicited by hypoglycemia.
T2D: Type 2 diabetes TNF-[alpha]: Tumor necrosis factor-a IL-6: Interleukin-6 JNK: Jun N-terminal kinase IKK[beta]: I[kappa]B kinase HFD: High-fat diet DPP-4: Dipeptidyl-peptidase 4 GLP-1: Glucagon-like peptide 1 GIP: Glucose-dependent insulinotropic peptide WAT: White adipose tissue DIO: Diet-induced obese RCT: Randomized controlled trial WT: Wild-type TC: Total cholesterol TG: Triglycerides GTT: Glucose tolerance test ITT: Insulin tolerance test AUC: Area under the curve H&E: Hematoxylin and eosin AP1: Activator protein 1 AMPK: AMP-activated protein kinase mTOR: Mammalian target of rapamycin NAFLD: Nonalcoholic fatty liver disease HOMA-IR: Homeostasis model assessment index-insulin resistance SEM: Standard error of the mean.
In order to measure insulin sensitivity, we performed an insulin tolerance test. Glimepiride-treated mice are as sensitive to insulin as control-treated mice (c).
C, Insulin tolerance test results for control (n=4 mice), HFD (n=4 mice) and HFD + rimonabant (n=4 mice) groups.
The insulin tolerance test revealed the suppression of C-peptide as well as the poor responses of ACTH and cortisol (Table 2(c)).

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