DOK5(redirected from Insulin receptor substrate 6)
DOK5A gene on chromosome 20q13.2 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK5 functions in RET-mediated neurite outgrowth and may be a downstream effector of RET in neuronal differentiation. It upregulates the MAP kinase pathway, and is highly expressed in skeletal muscle, less so in the brain, heart and kidneys.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.